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Haptoglobin Genotype and Its Role in Diabetic Cardiovascular Disease

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Abstract

Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the development of cardiovascular disease among individuals with diabetes mellitus.

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Acknowledgments

This study was supported by grants from NIH (R01DK085226), JDRF, BSF, and ISF to APL and grants from NIDDK (DK082900) and ADA (1-10-CT-12) to TC.

Potential Conflict of Interest

Dr. Levy is the author of a patent which is owned by his university which claims that the Hp genotype can predict the development of diabetic vascular complications. This patent has been licensed by Haptocure. Dr. Levy is serving as a consultant for Haptocure.

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  1. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Tina Costacou

  2. Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel

    Andrew P. Levy

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Correspondence to Tina Costacou.

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Costacou, T., Levy, A.P. Haptoglobin Genotype and Its Role in Diabetic Cardiovascular Disease. J. of Cardiovasc. Trans. Res. 5, 423–435 (2012). https://doi.org/10.1007/s12265-012-9361-z

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