Neuroscience Bulletin

, Volume 29, Issue 4, pp 501–508

Protective effects of Batroxobin on spinal cord injury in rats

  • Hong Fan
  • Xia Liu
  • Hai-Bin Tang
  • Peng Xiao
  • Ya-Zhou Wang
  • Gong Ju
Original Article

DOI: 10.1007/s12264-013-1354-7

Cite this article as:
Fan, H., Liu, X., Tang, HB. et al. Neurosci. Bull. (2013) 29: 501. doi:10.1007/s12264-013-1354-7

Abstract

Expansion of the secondary injury following primary spinal cord injury is a major pathological event that increases destruction in the spinal cord, so measures to reduce secondary injury are needed. Our previous study demonstrated that, at the front of the expanding secondary injury in the spinal cord, there is an ischemic area in which many neurons can still be rescued. Therefore, enhancement of blood circulation in the cord may be helpful, and indeed, we found that a traditional Chinese medicine, shu-xue-tong, efficiently reduces the secondary injury. The aim of the present study was to investigate the effect of reducing fibrinogen with Batroxobin, a drug widely used clinically for ischemia, in rats with spinal cord contusion. We found that both 2 and 4 Batroxobin units (BU)/kg efficiently decreased the plasma fibrinogen, and 2 BU/kg significantly increased spinal blood flow, enhanced neuronal survival, mitigated astrocyte and microglia activation, and improved locomotor recovery. However, 4 BU/kg had no effect on the secondary spinal cord injury. These data suggest that Batroxobin has multiple beneficial effects on spinal cord injury, indicating a potential clinical application.

Keywords

spinal cord injurysecondary injuryfibrinogenBatroxobin

Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hong Fan
    • 1
  • Xia Liu
    • 2
  • Hai-Bin Tang
    • 3
  • Peng Xiao
    • 1
  • Ya-Zhou Wang
    • 1
  • Gong Ju
    • 1
  1. 1.Institute of NeurosciencesFourth Military Medical UniversityXi’anChina
  2. 2.Department of RehabilitationPLA General Hospital of Air ForceBeijingChina
  3. 3.Department of Laboratory MedicineXi’an Central HospitalXi’anChina