Review

Neuroscience Bulletin

, Volume 29, Issue 2, pp 155-164

Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives

  • Hao HuangAffiliated withInstitute of Developmental and Regenerative Biology, College of Life Sciences, Hangzhou Normal University
  • , Xiao-Feng ZhaoAffiliated withInstitute of Developmental and Regenerative Biology, College of Life Sciences, Hangzhou Normal University
  • , Kang ZhengAffiliated withInstitute of Developmental and Regenerative Biology, College of Life Sciences, Hangzhou Normal University
  • , Mengsheng QiuAffiliated withInstitute of Developmental and Regenerative Biology, College of Life Sciences, Hangzhou Normal UniversityDepartment of Anatomical Sciences and Neurobiology, University of Louisville Email author 

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Abstract

Axonal myelination is an essential process for normal functioning of the vertebrate central nervous system. Proper formation of myelin sheaths around axons depends on the timely differentiation of oligodendrocytes. This differentiation occurs on a predictable schedule both in culture and during development. However, the timing mechanisms for oligodendrocyte differentiation during normal development have not been fully uncovered. Recent studies have identified a large number of regulatory factors, including cell-intrinsic factors and extracellular signals, that could control the timing of oligodendrocyte differentiation. Here we provide a mechanistic and critical review of the timing control of oligodendrocyte differentiation.

Keywords

oligodendrocytes differentiation timing remyelination