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Antioxidative effect of phycoerythrin derived from Grateloupia filicina on rat primary astrocytes

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Abstract

Astrocytes, which support neuronal tissue and activity in the brain, are receiving attention as a possible target for treating neurological damage. Phycoerythrin extract, a pigment protein of red algae, is known to have anti-inflammatory, anti-cancer, and anti-viral effects. In this study, Phycoerythrin extract from Grateloupia filicina (GfPE) was used to treat astrocytes and then assessed for its ability to protect against physiological changes under oxidative stress via H2O2. GfPE had a good effect on viability and proliferation of astrocytes that were downregulated under oxidative stress. Accordingly, GfPE alleviated the increasing effect of H2O2 on ROS of astrocytes.

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Authors and Affiliations

  1. Department of Biological Engineering, Inha University, Incheon, 402-751, Korea

    Sang-Myung Jung, Jun Sang Park, Hyun Jung Shim, Yeo Seon Kwon & Hwa Sung Shin

  2. Department of Marine Bioscience, Gangneung-Wonju National University, Gangneung, 210-702, Korea

    Hyung Geun Kim

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  1. Sang-Myung Jung
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  2. Jun Sang Park
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  5. Hyung Geun Kim
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  6. Hwa Sung Shin
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Correspondence to Hwa Sung Shin.

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The first two authors have contributed equally to this work.

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Jung, SM., Park, J.S., Shim, H.J. et al. Antioxidative effect of phycoerythrin derived from Grateloupia filicina on rat primary astrocytes. Biotechnol Bioproc E 21, 676–682 (2016). https://doi.org/10.1007/s12257-016-0369-0

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  • DOI: https://doi.org/10.1007/s12257-016-0369-0

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