Summary
Out of the numerous papers dealing with lymphoma at the American Society of Hematology (ASH) 2015 meeting, three could change clinical practice. The DA-EPOCH-R regimen has improved the evidence for efficacy in Burkitt lymphoma. For lymphoproliferative disease after solid organ transplantation rituximab is a reasonable first-line treatment and nonresponders can be salvaged with R‑CHOP. For anaplastic large cell lymphoma the addition of etoposide to the CHOP regimen is an option. However, better regimens with new drugs are eagerly awaited.
Similar content being viewed by others
References
Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–90.
Fridrik MA. (editor) Burkitt and lymphoblastic lymphoma. Rickmansworth: ESMO Press s/s/media limited; 2012.
Dunleavy K, Pittaluga S, Shovlin M, Steinberg SM, Cole D, Grant C, et al. Low-intensity therapy in adults with Burkitt’s lymphoma. N Engl J Med. 2013;369(20):1915–25.
Offner F, Samoilova O, Osmanov E, Eom H‑S, Topp MS, Raposo J, et al. Frontline rituximab, cyclophosphamide, doxorubicin, and prednisone with bortezomib (VR-CAP) or vincristine (R-CHOP) for non-GCB DLBCL. Blood. 2015;126(16):1893–901.
Ribrag V, Tilly H, Casasnovas O, Bosly A, Bouabdallah R, Delarue R, et al. Final results of a randomized phase 2 multicenter study of two Bortezomib schedules in patients with recurrent or refractory follicular lymphoma. Groupe d’etude des Lymphomes de l’Adulte (GELA) study FL-05. Blood. 2010;116(21):768.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
M. A. Fridrik is consultant for Roche and has received honoraria and other renumerations from the company.
Rights and permissions
About this article
Cite this article
Fridrik, M.A. Practice changing information in aggressive lymphoma, ASH 2015. memo 9, 124–126 (2016). https://doi.org/10.1007/s12254-016-0271-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12254-016-0271-7