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Prognostic Impact of Different Histological Types on Gastric Adenocarcinoma: a Surveillance, Epidemiology, and End Results Database Analysis

  • Original Article
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Pathology & Oncology Research

Abstract

The clinicopathological characteristics and prognosis of gastric mucinous adenocarcinoma (MAC) and signet ring cell carcinoma (SRC) are still controversial. We designed our study to evaluate the clinicopathologic features and prognosis of MAC, SRC and ordinary gastric adenocarcinoma (OGAC) by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database. The 5-year overall survival (OS) of patients with SRC was significantly lower than that of patients with MAC (P = 0.001) and OGAC (P < 0.001), and there was no significant difference in 5-year OS between MAC and OGAC (P = 0.804). Furthermore, there were no significant differences of 5-years OS among these three groups at stage I, II and III (all P > 0.05) and no significant difference between MAC and OGAC at stage IV (P = 0.110). Patients in SRC group had significantly worse survival than those in MAC and OGAC at stage IV (both P = 0.008), with 5-year OS of 3.3%, 5.8%, and 5.8%, respectively. However, the histological type was not found to be an independent prognostic factor of gastric cancer according to the multivariate analysis with Cox regression.

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Acknowledgement

The authors acknowledge the efforts of the Surveillance, Epidemiology, and End Results (SEER) Program tumor registries in the creation of the SEER database. The interpretation and reporting of these data are the sole responsibility of the authors. The authors have no support or funding to report.

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Authors and Affiliations

  1. Department of Radiation Oncology, Lihuili Hospital, Ningbo Medical Center, No. 57, Xing’Ning Road, Ningbo, 315041, China

    Kaitai Liu, Yanping Bei, Xue Chen & Miaozhen Lu

  2. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

    Juefeng Wan

  3. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Juefeng Wan

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  1. Kaitai Liu
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  2. Juefeng Wan
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  3. Yanping Bei
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  4. Xue Chen
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  5. Miaozhen Lu
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Corresponding author

Correspondence to Miaozhen Lu.

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KTL and JFW conceived of and designed the study. KTL, JFW and YPB performed the analyses. YPB and XC prepared all tables. KTL and MZL wrote the main manuscript. All authors reviewed the manuscript.

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The authors declare that they have no competing interests.

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Kaitai Liu and Juefeng Wan contributed equally to this work.

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Liu, K., Wan, J., Bei, Y. et al. Prognostic Impact of Different Histological Types on Gastric Adenocarcinoma: a Surveillance, Epidemiology, and End Results Database Analysis. Pathol. Oncol. Res. 23, 881–887 (2017). https://doi.org/10.1007/s12253-017-0198-2

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  • DOI: https://doi.org/10.1007/s12253-017-0198-2

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