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Overexpression of Aquaporin-1 is a Prognostic Factor for Biochemical Recurrence in Prostate Adenocarcinoma

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Pathology & Oncology Research

Abstract

Aquaporins (AQP) are transmembrane proteins that provide channels for water and solutes, and some are involved in tumor progression and invasion. We evaluated the expression of AQP-1, AQP-3, and AQP-5 and their clinicopathological significance in prostate adenocarcinomas (PCA). Prostatectomy specimens (n = 99) were retrieved from the surgical pathology archives and clinicopathological data were obtained from the medical database at Kyungpook National University Hospital. Immunohistochemical staining for AQP-1, AQP-3, and AQP-5 was performed on tissue microarrays comprising paired malignant and benign prostatic tissues. Seventeen PCA cases (17.2 %) showed AQP-1 overexpression, specifically 7 tumors (9.7 %) with lower Gleason scores (GS) and 10 tumors (37.0 %) with higher GS, with statistical significance (P = 0.001). AQP-1 overexpression was significantly associated with higher GS (P = 0.001), higher pathologic T (pT) stages (P = 0.024), and biochemical recurrence (BR) (P = 0.002). The difference in AQP-3 and AQP-5 expression between neoplastic and non-neoplastic tissues was not established and there were no correlations with clinicopathological parameters. AQP-1 overexpression was evident in tumors with higher GS, it was less evident in tumors with lower GS, and it was associated with BR and a higher pT stage. AQP-1 overexpression is associated with prostate cancer progression.

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Acknowledgments

We appreciate the kind and efficient experimental assistance provided by Hwa-young Lee at Kyungpook National University Hospital, School of Medicine, Daegu, Korea.

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Authors and Affiliations

  1. Department of Pathology, Daegu Catholic University Medical Center, School of Medicine, Catholic University of Daegu, Duryugongwon-ro 17-gil, Nam-gu, Daegu, 42472, Republic of Korea

    Ji Y. Park

  2. Department of Pathology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Republic of Korea

    Ji Y. Park & GhilSuk Yoon

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  1. Ji Y. Park
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Correspondence to Ji Y. Park.

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The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

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Park, J.Y., Yoon, G. Overexpression of Aquaporin-1 is a Prognostic Factor for Biochemical Recurrence in Prostate Adenocarcinoma. Pathol. Oncol. Res. 23, 189–196 (2017). https://doi.org/10.1007/s12253-016-0145-7

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  • DOI: https://doi.org/10.1007/s12253-016-0145-7

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