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Dystroglycan is Associated with Tumor Progression and Patient Survival in Gastric Cancer

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Pathology & Oncology Research

Abstract

Previous reports had indicated that there was a possible correlation of dystroglycan (DG) with biological behavior of cancer cells and cancer patients’ survival. However, the role of DG expression in gastric cancer was rarely studied. In this study, α-DG and β-DG expression were determined by immunohistochemistry in specimens of primary cancer, metastatic lymph node, distal metastatic lesion, and their normal counterpart tissues in 20 gastric cancer patients. Correlations between α-DG and β-DG expression and prognosis were retrospectively analyzed. Our results found that positive expression of α-DG in normal mucosa, paired primary tumor, metastatic lymph node and distal metastatic site was detected in 95%, 70%, 25%, and 5% specimens, individually. Regarding β-DG,it was 70%, 55%, 10%, and 10%, individually. Patients who had lower α-DG expression in tumors than in normal counterparts showed poor survival (p = 0.002), whereas such a correlation was not found in the case of β-DG (p = 0.079). Difference of α-DG between primary tumor and its normal counterparts was an independent prognostic factor in gastric cancer with distal metastasis. This study showed DG expression was gradually reduced during tumor progression. Different expression of α-DG, but not β-DG, between primary tumor and normal specimen, correlated with patient survival, implicating a potential marker for gastric cancer prognosis.

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Abbreviations

DG:

dystroglycan

ECM:

extracellular matrix

mLN:

metastatic lymph node

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Acknowledgments

This study was supported by Science and Health Care Foundation grant, which is funded by the Health Bureau, Zhejiang Province, China (2007B115, 2009A110).

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Authors and Affiliations

  1. Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China

    Jian Guo Shen, Chao Yang Xu, Ming Jun Dong & Lin Bo Wang

  2. Department of Medical Oncology, Hangzhou First People’s Hospital, Hangzhou, 310016, China

    Xin Li

  3. Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Zi Nong Jiang & Jin Wang

Authors
  1. Jian Guo Shen
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  2. Chao Yang Xu
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  3. Xin Li
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  4. Ming Jun Dong
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  5. Zi Nong Jiang
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  6. Jin Wang
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  7. Lin Bo Wang
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Correspondence to Lin Bo Wang.

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Shen, J.G., Xu, C.Y., Li, X. et al. Dystroglycan is Associated with Tumor Progression and Patient Survival in Gastric Cancer. Pathol. Oncol. Res. 18, 79–84 (2012). https://doi.org/10.1007/s12253-011-9419-2

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  • DOI: https://doi.org/10.1007/s12253-011-9419-2

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