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Neutrophils influx and proinflammatory cytokines inhibition by sodium salicylate, unlike aspirin, in Candida albicans-induced peritonitis model

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Abstract

Sodium salicylate (NaS) and aspirin (ASA) are known to have a variety of effects on microorganisms, such as fungus (C. albicans and C. neoformans), moreover, it have effects in leukocyte adhesion and migration in vitro. In this report, we investigated the effect of ASA and NaS in neutrophil migration and cytokine production in C. albicans-induced peritonitis murine model. For this, mice were treated intraperitoneally (i.p) or orally (po) with NaS or ASA; after they were stimulated i.p. with C. albicans, the cellular migration was evaluated 24 h after stimulation. NaS, in mice treated i.p., unlike ASA, was able to inhibit the neutrophil migration and proinflammatory cytokine production induced by C. albicans, such as TNF-α, IL-1, IFN-γ, IL-12, and IL-10, but did not alter the IL-4 levels in these animals. However, the po treatment with same the dose of NaS or ASA did not affect the influx of this cell for inflammatory site. These results suggest that the NaS inhibits cellular migration and proinflammatory cytokine by different anti-inflammatory mechanism compared to ASA.

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Acknowledgments

This work was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Federal University of Pará/PA. M. C. Monteiro and L. H. Faccioli are recipients of fellowship from CNPq. The authors declare no conflict of interest.

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Authors and Affiliations

  1. Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, USP-SP, Ribeirão Preto, Brazil

    Priscilla Aparecida Tártari Pereira

  2. Departamento de Biologia, Universidade Estadual do Centro-Oeste/UNICENTRO, Guarapuava, PR, Brazil

    Daniel Bini

  3. Departamento de Anatomia Patológica, Universidade Federal do Paraná/PR, Paraná, Brazil

    Fernanda Bovo

  4. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP-SP, Ribeirão Preto, Brazil

    Priscilla Aparecida Tártari Pereira & Lucia Helena Faccioli

  5. Pós-graduação em Ciências Farmacêuticas, Pós-graduação em Neurociências e Biologia celular, Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará/UFPA, Rua Augusto Correia, Belém, PA, Brazil

    Marta Chagas Monteiro

  6. Endereço: Laboratório de Microbiologia e Imunologia Clínica, Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará/UFPA, Rua Augusto Correia, Belém, PA, Brazil

    Marta Chagas Monteiro

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Pereira, P.A.T., Bini, D., Bovo, F. et al. Neutrophils influx and proinflammatory cytokines inhibition by sodium salicylate, unlike aspirin, in Candida albicans-induced peritonitis model. Folia Microbiol 61, 337–346 (2016). https://doi.org/10.1007/s12223-016-0443-1

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