Skip to main content
SpringerLink
Log in

Pediatric follicular lymphoma in Japan

  • Original Article
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

Follicular lymphoma (FL) is quite rare in children. There have been only two major reports on pediatric FL. The present retrospective study on pediatric FL in Japan, including FL with diffuse large B cell lymphoma (DLBCL), analyzed data from 1991 to 2014. Twenty-two patients with pediatric FL were analyzed. Sixteen patients were boys and six were girls. Median age of onset was 9 years (range 4–17 years). In 11 patients, DLBCL co-existed with FL. The initial lesions involved cervical lesions in 16 patients, and the abdomen in six. With regard to stage of disease at diagnosis, 17 patients were at stage I or II, four were at stage III, and one was at stage IV. Chemotherapy was administered in 18 patients, and only resection was performed in four patients. Mature B lymphoma regimens were selected for 17 patients who received chemotherapy. Although two patients relapsed, all patients are currently alive and disease free. The median follow-up period was 54.5 months (range 6–126 months). Patients having FL with DLBCL were younger compared with those having FL, and this disease was more frequently observed in female patients. Our data revealed that FL in Japanese children is a tumor with good prognosis, as in reports from the United States and Europe.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kobayashi R, Sunami S, Mitsui T, Nakazawa A, Koga Y, Mori T, et al. Treatment of pediatric lymphoma in Japan: current status and plans for the future. Pediatr Int. 2015;57:523–34.

    Article  PubMed  Google Scholar 

  2. Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, Sandlund JT, et al. Clinicopathologic analysis of follicular lymphoma occurring in children. Blood. 2002;99:1959–64.

    Article  CAS  PubMed  Google Scholar 

  3. Oschlies I, Salaverria I, Mahn F, Meinhardt A, Zimmermann M, Woessmann W, et al. Pediatric follicular lymphoma—a clinico-pathological study of a population-based series of patients treated within the non-Hodgkin’s Lymphoma–Berlin-Frankfurt-Munster (NHL–BFM) multicenter trials. Haematologica. 2010;95:253–9.

    Article  PubMed  Google Scholar 

  4. Harris NL, Nathwani BN, Swerdlow SH, et al. Follicular lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC; 2008.

    Google Scholar 

  5. Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.

    Article  CAS  PubMed  Google Scholar 

  6. Disease registration committee, Japanese Society of Pediatric Hematology and Oncology. The report of epidemiologic study from 2009 to 2011. Jpn J Pediatr Hematol/Oncol. 2013;50:462–78.

    Google Scholar 

  7. Federico M, Bellei M, Marcheselli L, Luminari S, Lopez-Guillermo A, Vitolo U, et al. Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project. J Clin Oncol. 2009;27:4555–62.

    Article  PubMed  Google Scholar 

  8. Swerdlow S, Campo E, Harris N. World Health Organization classification of tumours of aematopoietic and lymphoid tissues. Lyon: IARC Press; 2008.

    Google Scholar 

  9. Attarbaschi A, Beishuizen A, Mann G, Rosolen A, Mori T, Uyttebroeck A, et al. European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Study Group. Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a “Watch and wait” strategy after complete resection. Ann Hematol. 2013;92:1537–41.

    Article  CAS  PubMed  Google Scholar 

  10. Yuen AR, Kamel OW, Halpern J, Horning SJ. Long-term survival after histologic transformation of low-grade follicular lymphoma. J Clin Oncol. 1995;13:1726–33.

    Article  CAS  PubMed  Google Scholar 

  11. Advani R, Rosenberg SA, Horning SJ. Stage I and II follicular non-Hodgkin’s lymphoma: long-term follow-up of no initial therapy. J Clin Oncol. 2004;22:1454–9.

    Article  PubMed  Google Scholar 

  12. Al-Tourah AJ, Gill KK, Chhanabhai M, Hoskins PJ, Klasa RJ, Savage KJ, et al. Population-based analysis of incidence and outcome of transformed non-Hodgkin’s lymphoma. J Clin Oncol. 2008;26:5165–9.

    Article  PubMed  Google Scholar 

  13. Bains P, Al Tourah A, Campbell BA, Pickles T, Gascoyne RD, Connors JM, et al. Incidence of transformation to aggressive lymphoma in limited-stage follicular lymphoma treated with radiotherapy. Ann Oncol. 2013;24:428–32.

    Article  CAS  PubMed  Google Scholar 

  14. Bastion Y, Sebban C, Berger F, Felman P, Salles G, Dumontet C, et al. Incidence, predictive factors, and outcome of lymphoma transformation in follicular lymphoma patients. J Clin Oncol. 1997;15:1587–94.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This research was supported by Practical Research for Innovative Cancer Control of the Japan Agency for Medical Research and Development (AMED). We also thank the doctors of the JPLSG for their participation this study.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Sapporo Hokuyu Hospital, Higashi-Sapporo 6-6, Shiroishiku, Sapporo, Hokkaido, 003-0006, Japan

    Ryoji Kobayashi

  2. Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

    Ryoji Kobayashi

  3. Department of Pediatrics, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan

    Fumiko Tanaka

  4. Department of Pathology, National Center for Child Health and Development, Tokyo, Japan

    Atsuko Nakazawa

  5. Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine, Yonago, Japan

    Jun-ichi Ueyama

  6. Department of Pediatrics, Japanese Red Cross Narita Hospital, Narita, Japan

    Shosuke Sunami

  7. Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan

    Tetsuo Mitsui

  8. Department of Pediatrics, Kyushu University Graduate School of Medicine, Fukuoka, Japan

    Yuhki Koga

  9. Department of Pediatrics, Kobe University School of Medicine, Kobe, Japan

    Takeshi Mori

  10. Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan

    Tomoo Osumi

  11. Department of Pediatrics, National Hospital Organization Kyusyu Cancer Center, Fukuoka, Japan

    Reiji Fukano

  12. Department of Hematology and Oncology, Gunma Children’s Medical Center, Shibukawa, Japan

    Kentaro Ohki

  13. Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

    Masahiro Sekimizu

  14. Department of Pediatrics, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan

    Naoto Fujita

  15. Department of Pediatrics, School of Medicine, Nagoya City University, Nagoya, Japan

    Michi Kamei

  16. Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan

    Tetsuya Mori

Authors
  1. Ryoji Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fumiko Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Atsuko Nakazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jun-ichi Ueyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shosuke Sunami
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tetsuo Mitsui
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yuhki Koga
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Takeshi Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Tomoo Osumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Reiji Fukano
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kentaro Ohki
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Masahiro Sekimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Naoto Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Michi Kamei
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Tetsuya Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

Lymphoma Committee and Japanese Pediatric Leukemia/Lymphoma Study Group

Corresponding author

Correspondence to Ryoji Kobayashi.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest to disclose.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kobayashi, R., Tanaka, F., Nakazawa, A. et al. Pediatric follicular lymphoma in Japan. Int J Hematol 105, 849–853 (2017). https://doi.org/10.1007/s12185-017-2209-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12185-017-2209-1

Keywords

Search

Navigation