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Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion

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Abstract

A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integration sites revealed a clonal disease, distinct from the first tumor.

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Author information

Authors and Affiliations

  1. Département d’Immunologie Clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), 1 avenue Claude Vellefaux, 75010, Paris, France

    Eric Oksenhendler, Raphael Lhote, Claire Fieschi & Lionel Galicier

  2. EA3518, Université Paris Diderot Paris 7, Paris, France

    Eric Oksenhendler

  3. Section of Virology, Division of Infectious Diseases, Imperial College, London, W2 1PG, UK

    Jocelyn Turpin & Charles Bangham

  4. Unité d’Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, 75015, Paris, France

    Olivier Cassar & Antoine Gessain

  5. CNRS, UMR3569, 75015, Paris, France

    Olivier Cassar & Antoine Gessain

  6. Laboratoire d’Hématologie, Université Paris-Diderot, Sorbonne Paris Cité, Institut Universitaire d’Hématologie, EA3518, Hôpital Saint-Louis, AP-HP, Paris, France

    Jean-Michel Cayuela

  7. Inserm U1126, Centre Hayem, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, Paris, France

    Claire Fieschi

  8. Department of Pathology, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), Paris, France

    Veronique Meignin

Authors
  1. Eric Oksenhendler
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  2. Jocelyn Turpin
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  3. Raphael Lhote
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  4. Olivier Cassar
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  5. Jean-Michel Cayuela
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  6. Claire Fieschi
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  7. Lionel Galicier
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  8. Veronique Meignin
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  9. Charles Bangham
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  10. Antoine Gessain
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Corresponding author

Correspondence to Eric Oksenhendler.

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Conflict of interest

The authors declare they have no conflict of interest.

Funding

This work was supported by the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” (Grant No. ANR-10-LABX-62-IBEID) and by a Wellcome Trust Senior Investigator Award.

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Oksenhendler, E., Turpin, J., Lhote, R. et al. Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion. Int J Hematol 105, 859–862 (2017). https://doi.org/10.1007/s12185-016-2174-0

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  • DOI: https://doi.org/10.1007/s12185-016-2174-0

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