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Aggressive transformation of anaplastic large cell lymphoma with increased number of ALK-translocated chromosomes

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Abstract

Pediatric anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) usually has a benign clinical course. A small fraction of patients with ALCL develops an aggressive clinical course; however, its etiology remains unclear. Here we report on an ALK-positive ALCL patient, who had complex translocations with TPM3-ALK revealed by RNA sequencing, with a very aggressive clinical course. On admission, the patient had extraordinarily high white blood cell count with double ALK-translocated chromosomes, and subsequently developed a more aggressive transformation with invasion into multiple organs with triple ALK-translocated chromosomes. The aggressive clinical course may have been related to these additional chromosomal aberrations. Our report provides new insights into the clonal evolution in ALCL and suggests the importance of monitoring examinations including fluorescence in situ hybridization analysis.

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Acknowledgments

This study was supported by the Project for the Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to JT).

Conflict of interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan

    Akihiro Hoshino, Keiko Nomura & Hirokazu Kanegane

  2. Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Takeru Hamashima

  3. Student of Tokyo University School of Medicine, Tokyo, Japan

    Tomoya Isobe

  4. Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    Masafumi Seki, Mitsuteru Hiwatari & Junko Takita

  5. Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Kenichi Yoshida & Seishi Ogawa

  6. Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Yuichi Shiraishi, Kenichi Chiba & Satoru Miyano

  7. Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Hiroko Tanaka & Satoru Miyano

  8. Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Hirokazu Kanegane

Authors
  1. Akihiro Hoshino
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  2. Keiko Nomura
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  3. Takeru Hamashima
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  4. Tomoya Isobe
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  5. Masafumi Seki
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  6. Mitsuteru Hiwatari
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  7. Kenichi Yoshida
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  8. Yuichi Shiraishi
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  9. Kenichi Chiba
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  10. Hiroko Tanaka
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  11. Satoru Miyano
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  12. Seishi Ogawa
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  13. Junko Takita
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  14. Hirokazu Kanegane
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Corresponding author

Correspondence to Akihiro Hoshino.

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Hoshino, A., Nomura, K., Hamashima, T. et al. Aggressive transformation of anaplastic large cell lymphoma with increased number of ALK-translocated chromosomes. Int J Hematol 101, 198–202 (2015). https://doi.org/10.1007/s12185-014-1701-0

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  • DOI: https://doi.org/10.1007/s12185-014-1701-0

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