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Differing impacts of pretransplant serum ferritin and C-reactive protein levels on the incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Abstract

Studies have suggested an association between pretransplant serum levels of ferritin and C-reactive protein (CRP) and complications of allogeneic hematopoietic stem cell transplantation (HSCT). To evaluate the prognostic impact of these biomarkers on the development of acute and chronic graft-versus-host disease (GVHD), we retrospectively studied 211 patients who underwent allogeneic HSCT for hematologic diseases at our institution. The cumulative incidence rate of chronic GVHD at 3 years was 40.7 %. In the multivariate analysis, elevated CRP levels (≥2 mg/L) were significantly associated with a high incidence of chronic GVHD, whereas high ferritin levels (≥880 ng/mL) showed a tendency, though not statistically significant, to association with a low incidence of chronic GVHD. No significant association was observed between the pretransplant serum ferritin or CRP levels and the incidence of acute GVHD. Multivariate analysis indicated that high pretransplant serum ferritin levels were significantly associated with increases in treatment-related mortality and relapse rates. Overall, an elevated pretransplant serum ferritin level, but not an elevated serum CRP level, is a strong risk factor for overall mortality (hazard ratio, 2.16; P = 0.002). Our results also indicate that pretransplant serum CRP levels may be a useful biomarker for predicting the risk of chronic GVHD.

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Acknowledgments

The authors would like to thank Rie Goi and Mika Kobayashi for their expert data management and secretarial assistance, and all the staff of our transplant team for their dedicated care of the patients and donors. This work was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Soichiro Sakamoto, Hiroshi Kawabata, Tatsuki Uchiyama, Chisaki Mizumoto, Tadakazu Kondo, Kouhei Yamashita, Norimitsu Kadowaki & Akifumi Takaori-Kondo

  2. Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan

    Junya Kanda

  3. Division of Hematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, Saga, Japan

    Tatsuo Ichinohe

  4. Kobe City Medical Center General Hospital, Kobe, Japan

    Takayuki Ishikawa

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  1. Soichiro Sakamoto
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  2. Hiroshi Kawabata
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  3. Junya Kanda
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Correspondence to Hiroshi Kawabata.

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Sakamoto, S., Kawabata, H., Kanda, J. et al. Differing impacts of pretransplant serum ferritin and C-reactive protein levels on the incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Int J Hematol 97, 109–116 (2013). https://doi.org/10.1007/s12185-012-1229-0

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  • DOI: https://doi.org/10.1007/s12185-012-1229-0

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