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Modified QuEChERS Combination with Magnetic Solid-Phase Extraction for the Determination of 16 Preservatives by Gas Chromatography–Mass Spectrometry

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Abstract

In this paper, based on the mechanism of the quick, easy, cheap, effective, rugged and safe (QuEChERS) method, a novel graphene grafted silica-coated Fe3O4 (Fe3O4@SiO2@G) was synthesized and applied as the efficient magnetic solid-phase extraction (MSPE) adsorbent for rapid cleanup of vegetable samples prior to analyzing 16 preservative residues by gas chromatography–mass spectrometry (GC-MS). The method, which took advantages of the novel nanoparticle adsorbent and an external magnetic field separation targets from samples, not only could avoid the time consuming of the traditional solid-phase extraction, but also could be developed for simultaneous determination of 16 preservative residues in vegetables. Various experimental parameters that could affect the extraction efficiencies have been investigated. Under the optimum conditions, 16 preservatives showed good linearity over the range of 0.02–2.00 mg/L and correlation coefficients (R 2) of 0.9946–0.9998. The limits of detections (LODs) were in the range of 0.21–11.50 μg/kg. The recoveries of 16 preservatives ranged from 78.3 to 116.7 %, and the relative standard deviations (RSDs) ranged from 1.4 to 11.9 %.

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References

  • Anastassiades M, Lehotay SJ, Stajnbaher D, Schenck FJ (2003) Fast and easy multiresidue method employing acetonitrile extraction/partitioning and dispersive solid phase extraction for the determination of pesticide residues in produce. J AOAC Int 86:412–421

    CAS  Google Scholar 

  • Chen LG, Li B (2013) Magnetic molecularly imprinted polymer extraction of chloramphenicol from honey. Food Chem 141:23–28

    Article  CAS  Google Scholar 

  • Costa LG, Cole TB, Jarvik GP, Furlong CE (2003) Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annu Rev Med 54:371–392

    Article  CAS  Google Scholar 

  • Deng XJ, Guo QJ, Chen XP, Xue T, Wang H, Yao P (2014) Rapid and effective sample clean-up based on magnetic multiwalled carbon nanotubes for the determination of pesticide residues in tea by gas chromatography-mass spectrometry. Food Chem 145:853–858

    Article  CAS  Google Scholar 

  • Heidari H, Razmi H (2012) Multi-response optimization of magnetic solid phase extraction based on carbon coated Fe3O4 nanoparticles using desirability function approach for the determination of the organophosphorus pesticides in aquatic samples by HPLC-UV. Talanta 99:13–21

    Article  CAS  Google Scholar 

  • Hou X, Han M, Dai XH, Yang XF, Yi SG (2013) A multi residue method for the determination of 124 pesticides in rice by modified QuEChERS extraction and gas chromatography-tandem mass spectrometry. Food Chem 138:1198–1205

    Article  CAS  Google Scholar 

  • Kirkhorn SR, Schenker MB (2002) Current health effects of agricultural work: respiratory disease, cancer, reproductive effects, musculoskeletal injuries, and pesticide related illnesses. J Agric Saf Health 8:199–214

    Article  CAS  Google Scholar 

  • Lehotay SJ, Son KA, Kwon H, Koesukwiwat U, Fu WS, Mastovska K, Hoh E, Leepipatpiboon N (2010) Comparison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and vegetables. J Chromatogr A 1217:2548–2560

    Article  CAS  Google Scholar 

  • Li Z, Ma RY, Bai SS, Wang C, Wang Z (2014) A solid phase microextraction fiber coated with graphene poly (ethylene glycol) composite for the extraction of volatile aromatic compounds from water samples. Talanta 119:498–504

    Article  CAS  Google Scholar 

  • Ling DS, Xie HY, He YZ, Gan WE, Gao Y (2010) Determination of preservatives by integrative coupling method of headspace liquid-phase microextraction and capillary zone electrophoresis. J Chromatogr A 1217:7807–7811

    Article  CAS  Google Scholar 

  • Liu Q, Shi JB, Cheng MT, Li GL, Cao D, Jiang GB (2012) Preparation of graphene-encapsulated magnetic microspheres for protein/peptide enrichment and MALDI-TOF MS analysis. Chem Commun 48:1874–1876

    Article  CAS  Google Scholar 

  • Liu XL, Wang C, Wu QH, Wang Z (2014) Preconcentration of chlorophenols in water samples using three dimensional graphene based magnetic nanocomposite as absorbent. Chin Chem Lett 25:1185–1189

    Article  CAS  Google Scholar 

  • Liu XL, Zhou X, Wang C, Wu QH, Wang Z (2015) Magnetic three-dimensional graphene solid-phase extraction of chlorophenols from honey samples. Food Addit Contam A 32:40–47

    Article  Google Scholar 

  • Luo YB, Shi ZG, Gao Q, Feng YQ (2011) Magnetic retrieval of graphene: extraction of sulfonamide antibiotics from environmental water samples. J Chromatogr A 1218:1353–1358

    Article  CAS  Google Scholar 

  • Ma XX, Wang JT, Sun M, Wang WN, Wu QH, Wang C, Wang Z (2013) Magnetic solid phase extraction of neonicotinoid pesticides from pear and tomato samples using graphene grafted silica-coated Fe3O4 as the magnetic adsorbent. Anal Methods-UK 5:2809–2815

    Article  CAS  Google Scholar 

  • Panstruga R, Schulze-Lefert P (2003) Corruption of host seven-transmembrane proteins by pathogenic microbes: a common theme in animals and plants? Microbes Infect 5:429–437

    Article  CAS  Google Scholar 

  • Paya P, Anastassiades M, Mack D, Sigalova I, Tasdelen B, Oliva J, Barba A (2007) Analysis of pesticide residues using the quick easy cheap effective rugged and safe (QuEChERS) pesticide multiresidue method in combination with gas and liquid chromatography and tandem mass spectrometric detection. Anal Bioanal Chem 389:1697–1714

    Article  CAS  Google Scholar 

  • Salvador IM, Frenich AG, Gonzalez FJE, Vidal JLM (2006) Determination of organophosphorus pesticides in vegetables by GC with pulsed flame photometric detection, and confirmation by MS. Chromatographia 64:667–672

    Article  Google Scholar 

  • Tabani H, Fakhari AR, Shahsavani A, Behbahani M, Salarian M, Bagheri A, Nojavan S (2013) Combination of graphene oxide-based solid phase extraction and electro membrane extraction for the preconcentration of chlorophenoxy acid herbicides in environmental samples. J Chromatogr A 1300:227–235

    Article  CAS  Google Scholar 

  • Wang MM, Yan XP (2012) Fabrication of graphene oxide nanosheets incorporated monolithic column via one step room temperature polymerization for capillary electrochromatography. Anal Chem 84:39–44

    Article  CAS  Google Scholar 

  • Wang P, Yang X, Wang J, Cui J, Dong AJ, Zhao HT, Zhang LW, Wang ZY, Xu RB, Li WJ, Zhang YC, Zhang H, Jing J (2012) Multi-residue method for determination of seven neonicotinoid insecticides in grains using dispersive solid phase extraction and dispersive liquid-liquid micro-extraction by high performance liquid chromatography. Food Chem 134:1691–1698

    Article  CAS  Google Scholar 

  • Wang JT, Ji SJ, Ma RY, Wu QH, Wang C, Qiang J, Wang Z (2014a) Synthesis of magnetic Fe3O4 modified graphene nanocomposite and its application on the adsorption of some dyes from aqueous solution. Sep Purif Technol 49:861–867

    CAS  Google Scholar 

  • Wang L, Zang XH, Chang QY, Zhang GJ, Wang CZ (2014b) Determination of triazole fungicides in vegetable samples by magnetic solid phase extraction with graphene- coated magnetic nanocomposite as adsorbent followed by gas chromatography-mass spectrometry detection. Food Anal Method 7:318–325

    Article  Google Scholar 

  • Wu QH, Liu M, Ma XX, Wang WN, Wang C, Zang XH, Wang Z (2012) Extraction of phthalate esters from water and beverages using a graphene based magnetic nanocomposite prior to their determination by HPLC. Microchim Acta 177:23–30

    Article  CAS  Google Scholar 

  • Zhang XL, Niu HY, Zhang SX, Cai YQ (2010) Preparation of a chitosan-coated C18-functionalized magnetite nanoparticle sorbent for extraction of phthalate ester compounds from environmental water samples. Anal Bioanal Chem 397:791–798

    Article  CAS  Google Scholar 

  • Zhang XL, Niu HY, Pan YY, Shi YL, Cai YQ (2011) Modifying the surface of Fe3O4/SiO2 magnetic nanoparticles with C18/NH2 mixed group to get an efficient sorbent for anionic organic pollutants. J Colloid Interface Sci 362:107–112

    Article  CAS  Google Scholar 

  • Zhao GY, Song SJ, Wang C, Wu QH, Wang Z (2011a) Determination of triazine herbicides in environmental water samples by high performance liquid chromatography using graphene coated magnetic nanoparticles as adsorbent. Anal Chim Acta 708:155–159

    Article  CAS  Google Scholar 

  • Zhao Q, Wei F, Luo YB, Ding J, Xiao N, Feng YQ (2011b) Rapid magnetic solid-phase extraction based on magnetic multiwalled carbon nanotubes for the determination of polycyclic aromatic hydrocarbons in edible oils. Food Chem 59:12794–12800

    Article  CAS  Google Scholar 

  • Zhao PY, Wang L, Zhou L, Zhang FZ, Kang S, Pan CP (2012) Multi walled carbon nanotubes as alternative reversed-dispersive solid phase extraction materials in pesticide multi-residue analysis with QuEChERS method. J Chromatogr A 1225:17–25

    Article  CAS  Google Scholar 

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Acknowledgments

This work was supported by “Food and agricultural research fund project (No. cstc2013yykfB0165)” and “Youth science and technology talents fund project (No. cstc2014kjrc-qnrc00002)” of Chongqing Municipal Science and Technology Commission of the People’s Republic of China.

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Authors and Affiliations

  1. College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China

    Yaling Chen & Zhiqiong Chen

  2. Chongqing Entry-Exit Inspection and Quarantine Bureau, Chongqing Engineering Technology, Research Center of Import and Export Food Safety, Chongqing, 400020, China

    Shurui Cao, Lei Zhang & Cunxian Xi

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  1. Yaling Chen
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  2. Shurui Cao
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  3. Lei Zhang
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  4. Cunxian Xi
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  5. Zhiqiong Chen
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Correspondence to Zhiqiong Chen.

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Yaling Chen declares that she has no conflict of interest. Shurui Cao declares that she has no conflict of interest. Lei Zhang declares that he has no conflict of interest. Cunxian Xi declares that he has no conflict of interest. Zhiqiong Chen declares that she has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Chen, Y., Cao, S., Zhang, L. et al. Modified QuEChERS Combination with Magnetic Solid-Phase Extraction for the Determination of 16 Preservatives by Gas Chromatography–Mass Spectrometry. Food Anal. Methods 10, 587–595 (2017). https://doi.org/10.1007/s12161-016-0616-1

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  • DOI: https://doi.org/10.1007/s12161-016-0616-1

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