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Psychosocial Correlates of Atrial Natriuretic Peptide: A Marker of Vascular Health

  • Original Article
  • Published:
Annals of Behavioral Medicine

Abstract

Background

Psychosocial factors have been associated with cardiovascular outcomes, but few studies have examined the association between psychosocial function and natriuretic peptides.

Purpose

The purpose of this study is to determine the predictive value of hostility, anger, and social support in relation to atrial natriuretic peptide (ANP), a marker of vascular health, among middle-aged men.

Methods

One hundred twenty-one men (mean age = 39.8 years, SD = 4.1) underwent assessments of ANP and completed the Cook–Medley Hostility Scale, the Spielberger State–Trait Anger Scale, and the Interview Schedule for Social Interaction.

Results

Higher levels of hostility (β = 0.22 [95 % CI 0.04, 0.40], P = 0.032) and trait anger (β = 0.18 [95 % CI 0.01, 0.37], P = 0.044) were associated with greater ANP levels. In contrast, higher perceived social support was also associated with lower ANP levels, (β = −0.19 [95 % CI −0.05, −0.41], P = 0.010).

Conclusions

Psychosocial factors, including hostility, anger, and social support, are associated with varying ANP levels among middle-aged men, independent of cardiovascular and behavioral risk factors.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

    Patrick Smith Ph.D., James Blumenthal Ph.D. & Andrew Sherwood Ph.D.

  2. School of Social Sciences and Humanities (Psychology), University of Tampere, Tampere, Finland

    Martti T. Tuomisto Ph.D. & Lauri Parkkinen MS

  3. Department of Psychiatry, Tampere University Hospital, Tampere, Finland

    Martti T. Tuomisto Ph.D. & Lauri Parkkinen MS

  4. School of Medicine, University of Tampere, Tampere, Finland

    Mika Kähönen MD, Ilkka Pörsti MD & Väinö Turjanmaa MD

  5. Tampere University Hospital, Tampere, Finland

    Mika Kähönen MD, Ilkka Pörsti MD & Väinö Turjanmaa MD

  6. Appleton Cardiology Thedacare, Appleton, WI, USA

    Silja Majahalme MD

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  1. Patrick Smith Ph.D.
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Smith, P., Tuomisto, M.T., Blumenthal, J. et al. Psychosocial Correlates of Atrial Natriuretic Peptide: A Marker of Vascular Health. ann. behav. med. 45, 99–109 (2013). https://doi.org/10.1007/s12160-012-9414-1

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