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Incidental focal 18F-FDG uptake in the frontal process of the maxilla on PET/CT: prevalence and clinical significance

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Abstract

Objective

We investigated the prevalence and clinical significance of incidental focal 18F-FDG uptake in the frontal process of the maxilla, mimicking malignancy on PET/CT.

Methods

From a total of 32,834 patients who underwent 18F-FDG PET/CT, patients with focal uptake in the frontal process of the maxilla were selected by a database search. For those patients, medical records including relevant imaging studies were reviewed.

Results

Thirty-nine patients (0.12 %) demonstrated focal uptake on PET/CT. On CT of PET/CT, all lesions showed ground-glass attenuation with or without bony expansion, consistent with fibrous dysplasia. When comparing previous PET/CT, follow-up PET/CT, and CT, a significant difference in degree of 18F-FDG uptake was noted, with no associated change in the size of maxillary lesions. There were no patients who had symptoms or signs related to maxillary lesions during follow-up.

Conclusion

Focal 18F-FDG uptake in the frontal process of the maxilla is a rare, incidental, and persistent finding with variable uptake and can represent a benign condition.

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References

  1. Choi JY, Lee KS, Kim HJ, Shim YM, Kwon OJ, Park K, et al. Focal thyroid lesions incidentally identified by integrated 18F-FDG PET/CT: clinical significance and improved characterization. J Nucl Med. 2006;47:609–15.

    PubMed  Google Scholar 

  2. Cho SK, Choi JY, Yoo J, Cheon M, Lee JY, Hyun SH, et al. Incidental focal 18F-FDG uptake in the prostate: clinical significance and differential diagnostic criteria. Nucl Med Mol Imaging. 2011;45:192–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Park SB, Choi JY, Lee EJ, Yoo J, Cheon M, Cho SK, et al. Diagnostic criteria on 18F-FDG PET/CT for differentiating benign from malignant focal hypermetabolic lesions of parotid gland. Nucl Med Mol Imaging. 2012;46:95–101.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Choi JY, Lee KS, Kwon OJ, Shim YM, Baek CH, Park K, et al. Improved detection of second primary cancer using integrated 18F fluorodeoxyglucose positron emission tomography and computed tomography for initial tumor staging. J Clin Oncol. 2005;23:7654–9.

    Article  PubMed  Google Scholar 

  5. Yang BT, Wang YZ, Wang XY, Wang ZC, Xian JF, Li J. Fibrous dysplasia-like appearance of the frontal process of the maxilla on CT: prevalence in North China. AJNR Am J Neuroradiol. 2011;32:471–3.

    Article  CAS  PubMed  Google Scholar 

  6. Xu H, Zhang M, Zhai G, Li B. The clinical significance of 18F-FDG-PET/CT in early detection of second primary malignancy in cancer patients. J Cancer Res Clin Oncol. 2010;136:1125–34.

    Article  PubMed  Google Scholar 

  7. Xu GZ, Guan DJ, He ZY. 18FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis. Oral Oncol. 2011;47:560–5.

    Article  PubMed  Google Scholar 

  8. Chong VF, Khoo JB, Fan YF. Fibrous dysplasia involving the base of the skull. AJR Am J Roentgenol. 2002;178:717–20.

    Article  PubMed  Google Scholar 

  9. Stegger L, Juergens KU, Kliesch S, Wormanns D, Weckesser M. Unexpected finding of elevated glucose uptake in fibrous dysplasia mimicking malignancy: contradicting metabolism and morphology in combined PET/CT. Eur Radiol. 2007;17:1784–6.

    Article  PubMed  Google Scholar 

  10. Kao CH, Sun SS, Shen YY, Chen YK. Misdiagnosis of multiple bone metastases due to increased FDG uptake in polyostotic fibrous dysplasia. Clin Nucl Med. 2007;32:409–10.

    Article  PubMed  Google Scholar 

  11. Shigesawa T, Sugawara Y, Shinohara I, Fukii T, Mochizuki T, Morishige I. Bone metastasis detected by FDG PET in a patient with breast cancer and fibrous dysplasia. Clin Nucl Med. 2005;30:571–3.

    Article  PubMed  Google Scholar 

  12. Toba M, Hayashida K, Imakita S, Fukuchi K, Kume N, Shimotsu Y, et al. Increased bone mineral turnover without increased glucose utilization in sclerotic and hyperplastic change in fibrous dysplasia. Ann Nucl Med. 1998;12:153–5.

    Article  CAS  PubMed  Google Scholar 

  13. Aoki J, Watanabe H, Shinozaki T, Takagishi K, Ishijima H, Oya N, et al. FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions. Radiology. 2001;219:774–7.

    Article  CAS  PubMed  Google Scholar 

  14. Han J, Ryu JS, Shin MJ, Kang GH, Lee HK. Fibrous dysplasia with barely increased uptake on bone scan: a case report. Clin Nucl Med. 2000;25:785–8.

    Article  CAS  PubMed  Google Scholar 

  15. Machida K, Makita K, Nishikawa J, Ohtake T, Lio M. Scintigraphic manifestation of fibrous dysplasia. Clin Nucl Med. 1986;11:426–9.

    Article  CAS  PubMed  Google Scholar 

  16. Aras M, Ones T, Dane F, Nosheri O, Inanir S, Erdil TY, et al. False positive FDG PET/CT resulting from fibrous dysplasia of the bone in the work-up of a patient with bladder cancer: case report and review of the literature. Iran J Radiol. 2012;10:41–4.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Soonchunhyang University Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, Republic of Korea

    Soo Bin Park

  2. Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea

    Joon Young Choi, Kyung-Han Lee & Byung-Tae Kim

  3. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea

    Hyung-Jin Kim

  4. Department of Radiology, Kangnam Sacred Heart Hospital, Hallym University School of Medicine, Shingil-ro, Yeongdeungpo-gu, Seoul, 07441, Republic of Korea

    Hye Jeong Kim

Authors
  1. Soo Bin Park
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  2. Joon Young Choi
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  3. Hyung-Jin Kim
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  4. Hye Jeong Kim
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Correspondence to Joon Young Choi.

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Park, S.B., Choi, J.Y., Kim, HJ. et al. Incidental focal 18F-FDG uptake in the frontal process of the maxilla on PET/CT: prevalence and clinical significance. Ann Nucl Med 30, 619–623 (2016). https://doi.org/10.1007/s12149-016-1103-x

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  • DOI: https://doi.org/10.1007/s12149-016-1103-x

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