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A Review of Primary Osteosarcoma of the Larynx and Case Report

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Abstract

Sarcomas of the larynx are exceedingly uncommon, of which primary laryngeal osteosarcomas are the rarest. To date, 25 cases of primary laryngeal osteosarcomas have been reported in the literature. Laryngeal osteosarcomas may closely simulate sarcomatoid carcinomas, since both entities share clinical, histological and immunohistochemical features. Herein, we report a case of primary laryngeal osteosarcoma in a 55 year old male, focusing on the importance of light microscopic, immunohistochemical and ultrastructural features in accurately establishing the diagnosis. In addition, the current paper provides a review of the English language literature on the subject. Laryngeal osteosarcomas usually carry a dismal prognosis with no general consensus on the most effective mode of therapy. Similarly, the current patient developed bilateral lung metastases 8 months after the initial surgery.

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References

  1. Sanaat Z, Mohammady G, Esmaili H, Emrani M, Dolatkhah R. Osteosarcoma of the larynx. Arch Iran Med. 2009;12(5):499–502.

    PubMed  Google Scholar 

  2. Lewis JE, Barnes L, Tse LY, Hunt JL. Tumours of bone and cartilage. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World health organization classification of tumours. Lyon: IARC Press; 2005. p. 156–9.

    Google Scholar 

  3. Rosai RM, Landas SK, Kelly DR, Marsh WL. Osteosarcoma of the larynx. Otolaryngol Head Neck Surg. 1998;118:385–8.

    Article  Google Scholar 

  4. Kassir RR, Rassekh CH, Kinsella JB, Segas J, Carrau RL, Hokanson JA. Osteosarcoma of the head and neck: meta-analysis of randomised studies. Laryngoscope. 1997;107(1):56–61.

    Article  CAS  PubMed  Google Scholar 

  5. Athré RS, Vories A, Mudrovich S, Ducic Y. Osteosarcoma of the larynx. Laryngoscope. 2005;115(1):74–7.

    Article  PubMed  Google Scholar 

  6. Jackson C, Jackson CL. CH XXV—malignant diseases of the larynx. In: Jackson C, Jackson CL, editors. Diseases and injuries of the larynx. New York: Macmillan Publishing Company; 1942 plate XI.

    Google Scholar 

  7. Ulusan M, Yilmazer R, Ozluk Y, Enoz M, Suoglu Y. Radiation-induced osteosarcoma of the larynx: case report and literature review. Ear Nose Throat J. 2012;91(10):E22–5.

    PubMed  Google Scholar 

  8. Völker HU, Scheich M, Höller S, Ströbel P, Hagen R, Müller-Hermelink HK, Eck M. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor—report of two cases with similar morphology. Diagn Pathol. 2007;2:1. doi:10.1186/1746-1596-2-1.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Sheen TS, Wu CT, Hsieh T, Hsu MM. Postirradiation laryngeal osteosarcoma: case report and literature review. Head Neck. 1997;19(1):57–62.

    Article  CAS  PubMed  Google Scholar 

  10. Berge JK, Kapadia SB, Meyers EN. Osteosarcoma of the larynx. Arch Otolarnyngol Head Neck Surg. 1998;124(2):207–10.

    Article  CAS  Google Scholar 

  11. Mottola G, Cascone AM, Cavaliere M, Angrisani B, Fiorillo G, Parente G, Volino F, Lemma M. Osteosarcoma of the larynx: a case report. Cases J. 2008;1(1):365. doi:10.1186/1757-1626-1-365.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Topaloglu I, Işiksaçan V, Ulusoy S, Sişman S. Osteosarcoma of the larynx. Otolarnyngol Head Neck Surg. 2004;131(5):789–90.

    Article  Google Scholar 

  13. Myssiorek D, Patel M, Wasserman P, Rofeim O. Osteosarcoma of the larynx. Ann Otol Rhinol laryngol. 1998;107(1):70–4.

    Article  CAS  PubMed  Google Scholar 

  14. Pinsolle J, LeCluse I, Demeaux H, Laur P, Rivel J, Siberchicot F. Osteosarcoma of the soft tissue of the larynx: report of a case with electron microscopic studies. Otolaryngol Head Neck Surg. 1990;102(3):276–80.

    CAS  PubMed  Google Scholar 

  15. Marginal FM, Godoy LM, Daboin KP, Casiraghi O, Garcia AM, Luna MA. Laryngeal osteosarcoma: a clinicopathologic analysis of four cases and comparison with a carcinosarcoma. Ann Diagn Pathol. 2002;6(1):1–9.

    Article  Google Scholar 

  16. Van Laer CG, Helliwell TR, Atkinson MW, Stell PM. Osteosarcoma of the larynx. Ann Otol Rhinol Laryngol. 1989;98(12 Pt 1):971–4.

    Article  PubMed  Google Scholar 

  17. Laskin WB, Silverman TA, Enzinger FM. Postradiation soft tissue sarcomas: an analysis of 53 cases. Cancer. 1988;62(11):2330–40.

    Article  CAS  PubMed  Google Scholar 

  18. Remagen W, Löhr J, von Westernhagen B. Osteosarcoma of the larynx. HNO. 1983;31(10):366–8 (article in German).

    CAS  PubMed  Google Scholar 

  19. Suchatlampong V, Sriumpai S, Khawcharoenporn V. Osteosarcoma of the larynx: the first case report in Thailand with ultrastructural study. J Med Assoc Thai. 1981;64(6):301–7.

    CAS  PubMed  Google Scholar 

  20. Gorenstein A, Neel HB III, Weiland LH, Devine KD. Sarcomas of the larynx. Arch Otolaryngol. 1980;106(1):8–12.

    Article  CAS  PubMed  Google Scholar 

  21. Haar JG, Chaudhry AP, Karanjia MD, Milley PS. Chondroblastic osteosarcoma of the larynx. Arch Otolaryngol. 1978;104(8):477–81.

    Article  CAS  PubMed  Google Scholar 

  22. Dahm LJ, Schaefer SD, Carder HM, Vellios F. Osteosarcoma of the soft tissue of the larynx: report of a case with light and electron microscopic studies. Cancer. 1978;42(5):2343–51.

    Article  CAS  PubMed  Google Scholar 

  23. Morley AR, Cameron DS, Watson AJ. Osteosarcoma of the larynx. J Laryngol Otol. 1973;87(10):997–1005.

    Article  CAS  PubMed  Google Scholar 

  24. Sprinkle PM, Allen MS, Brookshire PF. Osteosarcoma of the larynx (a true primary sarcoma of the larynx). Laryngoscope. 1966;76(2):325–33.

    Article  CAS  PubMed  Google Scholar 

  25. Clerf LH. Sarcoma of the larynx; report of eight cases. Arch Otolaryngol. 1946;44(5):517–24.

    Article  CAS  PubMed  Google Scholar 

  26. Arslan M, Orhan-Kizilkaya H, Yalcin B, Aksakal O, Uyanoglu A, Ozturk S, et al. Larynx osteosarcoma: case report. J BUON. 2008;13(3):437–9.

    CAS  PubMed  Google Scholar 

  27. Lewis JE, Olsen KD, Sebo TJ. Spindle cell carcinoma of the larynx: review of 26 cases including DNA content and immunohistochemistry. Hum Pathol. 1997;28(6):664–73.

    Article  CAS  PubMed  Google Scholar 

  28. Gupta R, Singh S, Hedau S, Nigam S, Das BC, Singh I, Kumar A. Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis. J Clin Pathol. 2007;60(5):472–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Battifora H. Spindle cell carcinoma: ultrastructural evidence of squamous origin and collagen production by the tumor cells. Cancer. 1976;37(5):2275–82.

    Article  CAS  PubMed  Google Scholar 

  30. Thompson LDR, Wieneke LA, Miettinen M, Heffner DK. Spindle cell (sarcomatoid) carcinomas of the larynx. A clinicopathologic study of 187 cases. Am J Surg Pathol. 2002;26(2):153–70.

    Article  PubMed  Google Scholar 

  31. Viswanathan S, Rahman K, Pallavi S, Sachin J, Patil A, Chaturvedi P, D’Cruz A, Agarwal J, Kane SV. Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a Tertiary Referral Cancer Centre. Head Neck Pathol. 2010;4(4):265–75.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Zhang M, Zhao L-M, Li X-M, Zhou L, Lin L, Wang S-Y. True carcinosarcoma of the larynx. J Laryngol Otol. 2013;127(1):100–3.

    Article  CAS  PubMed  Google Scholar 

  33. Roy S, Purgina B, Seethala RR. Spindle cell carcinoma of the larynx with rhabdomyoblastic heterologous element: a rare form of divergent differentiation. Head Neck Pathol. 2013;7(3):263–7.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Hemingway F, Kashima TG, Mahendra G, Dhongre A, Hogendoorn PC, Mertens F, Athanasou NA. Smooth muscle actin expression in primary bone tumours. Virchows Arch. 2012;460(5):525–34.

    Article  CAS  PubMed  Google Scholar 

  35. Friedmann I. Osteoid and bone formation in a nasal mucosal melanoma and its metastasis. Histopathology. 1998;33(1):88.

    Article  CAS  PubMed  Google Scholar 

  36. Saleem M, Taibah K, Gangopadhyay K. Osteogenic sarcoma metastasizing to the larynx. J Otolaryngol. 2002;31(3):189–92.

    Article  PubMed  Google Scholar 

  37. Dellmann A, Schroeder HG, Donhuijsen K. Destructive tumours of the larynx mimicking osteosarcoma: two cases of osteoblastoma with organ-saving resection and follow-up. Eur Arch Otorhinolaryngol. 2010;267(1):151–4.

    Article  PubMed  Google Scholar 

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Oral & Maxillofacial Pathology, NHLS, Tygerberg Hospital Laboratories, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa

    Esraa Mosalleum, Amir Afrogheh & Jos Hille

  2. Division of Anatomical Pathology, NHLS, Tygerberg Hospital Laboratories, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa

    Johann Schneider

  3. Division of Otorhinolaryngology, Tygerberg Hospital, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa

    Sacha Stofberg

  4. Division of Radiodiagnosis, Tygerberg Hospital, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa

    Abraham Fourie Bezuidenhout

Authors
  1. Esraa Mosalleum
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  2. Amir Afrogheh
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Correspondence to Esraa Mosalleum.

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Mosalleum, E., Afrogheh, A., Stofberg, S. et al. A Review of Primary Osteosarcoma of the Larynx and Case Report. Head and Neck Pathol 9, 158–164 (2015). https://doi.org/10.1007/s12105-014-0550-8

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  • DOI: https://doi.org/10.1007/s12105-014-0550-8

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