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Expression of IMP3 and IGF2 in giant cell tumor of spine is associated with tumor recurrence and angiogenesis

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Abstract

Purpose

Giant cell tumor (GCT) of bone is a vessel-rich and infiltrative tumor, but the fundamental knowledge of its biological behavior remains unknown now.

Methods

In this study, we evaluated the expression levels of Insulin-like growth factor 2 mRNA-binding protein 3 (IMP3), Insulin-like growth factor 2 (IGF2) and CD105 in 38 patients with GCT of spine by Immunohistochemical staining. Additionally, we also analyzed their correlations with clinicopathological factors of giant cell tumor of spine.

Results

The results showed that positive expression of IMP3 and IGF2 was tightly related to the tumor extension and local recurrence of GCT (P < 0.05), but it did not indicate any association with patients’ age, gender, tumor location and size. The mean microvessel densities (MVDs) of IMP3 and IGF2 were significantly higher in positive group than negative group (P < 0.05). Moreover, a significant correlation was found between IMP3 and IGF2 expression (r = 0.355, P = 0.029). The log-rank test revealed that local recurrence-free survival time was significantly shorter in the IMP3 positive group (P = 0.004), and the difference in the IGF2 positive group and negative group was also statistically significant (P = 0.008).

Conclusion

IMP3 and IGF2 might be potential biomarkers for GCT of spine in regulating the angiogenesis of giant cell tumor of bone and predicting the patients’ prognosis.

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Acknowledgments

We would like to thank Yongping Gu for technical guidance during the immunohistochemical analysis. This study was funded by Jiangsu Provincial Special Program of Medical Science (BL2012004) and Suzhou city “Science and Education Guardian” Youth science and technology project (KJXW2014009).

Conflict of interest

The authors declare no conflict of interest.

Ethical standard

Our study was approved by the Committee on Medical Ethics of the First affiliated Hospital of Soochow University.

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Author notes

    Authors and Affiliations

    1. Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, Jiangsu, China

      K. Zhang, H. Chen, G. Wu, K. Chen & H. Yang

    2. Department of Orthopedic Surgery, Wuxi Ninth People’s Hospital Affiliated to Soochow University, 999 Liangxi Road, Wuxi, 214062, Jiangsu, China

      M. Zhou

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    1. K. Zhang
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    Correspondence to K. Chen or H. Yang.

    Additional information

    K. Zhang, M. Zhou and H. Chen contributed equally to this work.

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    Zhang, K., Zhou, M., Chen, H. et al. Expression of IMP3 and IGF2 in giant cell tumor of spine is associated with tumor recurrence and angiogenesis. Clin Transl Oncol 17, 570–575 (2015). https://doi.org/10.1007/s12094-015-1280-4

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    • DOI: https://doi.org/10.1007/s12094-015-1280-4

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