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Oral Fat Sensitivity in Humans: Links to Saliva Composition Before and After Stimulation by Oleic Acid

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Chemosensory Perception

Abstract

Fat perception is a complex sensation dependent on different sensory cues, such as texture and olfaction, and also potentially taste. In addition, saliva can interact with dietary fat during its consumption and influence the perception of fatty acids. Because previous studies had identified subjects who were hyper- and hyposensitive to the perception of free fatty acids, the first aim of this work was to study whether saliva composition is different in groups of subjects having low and high oral sensitivity to a free fatty acid, oleic acid (C18:1). The second aim was to determine whether oral stimulation with C18:1 could modify the composition of saliva. To verify these hypotheses, two groups of individuals were selected from a panel of 73 subjects: one group sensitive + to C18:1 (n = 12) and one sensitive − to C18:1 (n = 13). Overall, no differences were found in the saliva characteristics between the two groups. However, significant differences after C18:1 stimulation when comparing to a control stimulation were observed in the sensitive + group: in this group, the increase in antioxidant capacity and the decrease in lipolytic activity were significant, while it was not in the sensitive − group although the median values were similar for this last variable in the two groups. This would suggest that the response given by the salivary system to fatty acid stimulation is different in groups of subjects having low and high oral sensitivity to C18:1.

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Acknowledgments

The authors would like to thank Emilien di Sotto, Karim Oukhebbi and Hélène Brignot for their technical assistance with biochemical analyses and Dr. Martine Morzel for her valuable comments on the manuscript. This study was partly funded by the Burgundy Regional Council.

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Conflict of Interest

Rana Mounayar declares that she has no conflict of interest.

Chantal Septier declares that she has no conflict of interest.

Claire Chabanet declares that she has no conflict of interest.

Gilles Feron declares that he has no conflict of interest.

Eric Neyraud declares that he has no conflict of interest.

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. UMR6265 Centre des Sciences du Goût et de l’Alimentation, CNRS, 21000, Dijon, France

    Rana Mounayar, Chantal Septier, Claire Chabanet, Gilles Feron & Eric Neyraud

  2. UMR1324 Centre des Sciences du Goût et de l’Alimentation, INRA, 17 rue Sully, 21065, Dijon Cedex, France

    Rana Mounayar, Chantal Septier, Claire Chabanet, Gilles Feron & Eric Neyraud

  3. UMR Centre des Sciences du Goût et de l’Alimentation, Université de Bourgogne, 21000, Dijon, France

    Rana Mounayar, Chantal Septier, Claire Chabanet, Gilles Feron & Eric Neyraud

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  1. Rana Mounayar
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  2. Chantal Septier
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  3. Claire Chabanet
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Correspondence to Eric Neyraud.

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Mounayar, R., Septier, C., Chabanet, C. et al. Oral Fat Sensitivity in Humans: Links to Saliva Composition Before and After Stimulation by Oleic Acid. Chem. Percept. 6, 118–126 (2013). https://doi.org/10.1007/s12078-013-9152-1

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  • DOI: https://doi.org/10.1007/s12078-013-9152-1

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