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Impact of viral hepatitis B status on outcomes of intrahepatic cholangiocarcinoma: a meta-analysis

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Abstract

Background and aims

To estimate the impact of viral hepatitis B status on outcomes of intrahepatic cholangiocarcinoma.

Methods

We searched Pubmed and Embase for original articles that evaluated the impact of hepatitis B virus infection on outcomes of intrahepatic cholangiocarcinoma. The present study was conducted to generate odd ratios (ORs) with 95% confidence intervals (CIs) for pre-identified prognostic factors, overall survival, and recurrence.

Results

From 438 studies, we identified eight articles that compared outcomes between hepatitis B virus-infected patients and the others. In terms of clinicopathological characteristics, patients in the hepatitis B virus group significantly demonstrated single nodular tumor (OR 0.7; 95% CI 0.5–0.9; p = 0.01), infrequent lymph node metastasis (OR 0.5; 95% CI 0.3–0.6; p < 0.01), and infrequent perineural infiltration (OR 0.3; 95% CI 0.2–0.8; p < 0.01). No significant between-group differences were found in tumor diameter, vascular invasion, and tumor differentiation. Previous or temporary infection (seropositivity for hepatitis B core antibody) revealed no significant impact on clinicopathological characteristics. For survival outcomes, meta-analysis demonstrated that hepatitis B virus group had significantly better overall survival, recurrence rate, and median survival (p < 0.01).

Conclusions

Our results suggest that hepatitis B virus infection is a powerful predictor of favorable survival outcomes for intrahepatic cholangiocarcinoma and significantly affects clinicopathological characteristics. Viral hepatitis B status needs to be taken into account and then establish therapeutic approaches.

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References

  1. Razumilava N, Gores GJ. Cholangiocarcinoma. Lancet. 2014;383:2168–79.

    Article  PubMed  PubMed Central  Google Scholar 

  2. de Jong MC, Nathan H, Sotiropoulos GC, et al. Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol. 2011;29:3140–5.

    Article  PubMed  Google Scholar 

  3. Jeong S, Cheng Q, Huang L, et al. Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection. BMC Cancer. 2017;17:464.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Jeong S, Gao L, Tong Y, et al. Prognostic impact of cirrhosis in patients with intrahepatic cholangiocarcinoma following hepatic resection. Can J Gastroenterol Hepatol. 2017;2017:6543423.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Jeong S, Tong Y, Sha M, Gu J, Xia Q. Hepatitis B virus-associated intrahepatic cholangiocarcinoma: a malignancy of distinctive characteristics between hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Oncotarget. 2017;8:17292–300.

    PubMed  Google Scholar 

  6. Wang Q, Li J, Lei Z, et al. Prognosis of intrahepatic cholangiocarcinomas with HBV infection is better than those with hepatolithiasis after R0 liver resection: a propensity score matching analysis. Ann Surg Oncol. 2017;24:1579–87.

    Article  PubMed  Google Scholar 

  7. Ahn CS, Hwang S, Lee YJ, et al. Prognostic impact of hepatitis B virus infection in patients with intrahepatic cholangiocarcinoma. ANZ J Surg. 2018;88:212–7.

    Article  PubMed  Google Scholar 

  8. Tao LY, He XD, Xiu DR. Hepatitis B virus is associated with the clinical features and survival rate of patients with intrahepatic cholangiocarcinoma. Clin Res Hepatol Gastroenterol. 2016;40:682–7.

    Article  PubMed  Google Scholar 

  9. Liu RQ, Shen SJ, Hu XF, Liu J, Chen LJ, Li XY. Prognosis of the intrahepatic cholangiocarcinoma after resection: hepatitis B virus infection and adjuvant chemotherapy are favorable prognostic factors. Cancer Cell Int. 2013;13:99.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Wu ZF, Yang N, Li DY, Zhang HB, Yang GS. Characteristics of intrahepatic cholangiocarcinoma in patients with hepatitis B virus infection: clinicopathologic study of resected tumours. J Viral Hepat. 2013;20:306–10.

    Article  PubMed  CAS  Google Scholar 

  11. Peng NF, Li LQ, Qin X, et al. Evaluation of risk factors and clinicopathologic features for intrahepatic cholangiocarcinoma in Southern China: a possible role of hepatitis B virus. Ann Surg Oncol. 2011;18:1258–66.

    Article  PubMed  Google Scholar 

  12. Zhang L, Cai JQ, Zhao JJ, et al. Impact of hepatitis B virus infection on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol. 2010;101:233–8.

    Article  PubMed  Google Scholar 

  13. Gu J, Jeong S, Xia Q. Intrahepatic cholangiocarcinoma arising from HBV infection may be a highly selected population for liver transplantation. Hepatology. 2017;66:1703–4.

    Article  PubMed  Google Scholar 

  14. Wang Z, Sheng YY, Dong QZ, Qin LX. Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: a meta-analysis. World J Gastroenterol. 2016;22:3038–51.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Deeks JJ, Dinnes J, D’Amico R, et al. Evaluating non-randomised intervention studies. Health Technol Assess. 2003;7:iii–x (1–173).

    Article  PubMed  CAS  Google Scholar 

  16. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.

    Article  PubMed  Google Scholar 

  17. Iida H, Kaibori M, Tanaka S, et al. Low incidence of lymph node metastasis after resection of hepatitis virus-related intrahepatic cholangiocarcinoma. World J Surg. 2017;41:1082–8.

    Article  PubMed  Google Scholar 

  18. Lu Y, Lin N, Chen Z, Xu R. Hypoxia-induced secretion of platelet-derived growth factor-BB by hepatocellular carcinoma cells increases activated hepatic stellate cell proliferation, migration and expression of vascular endothelial growth factor-A. Mol Med Rep. 2015;11:691–7.

    Article  PubMed  CAS  Google Scholar 

  19. Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012;379:1245–55.

    Article  PubMed  Google Scholar 

  20. Thelen A, Scholz A, Weichert W, et al. Tumor-associated angiogenesis and lymphangiogenesis correlate with progression of intrahepatic cholangiocarcinoma. Am J Gastroenterol. 2010;105:1123–32.

    Article  PubMed  Google Scholar 

  21. Jeong S, Zheng B, Wang J, et al. Transarterial chemoembolization: a favorable postoperative management to improve prognosis of hepatitis B virus-associated intrahepatic cholangiocarcinoma after surgical resection. Int J Biol Sci. 2017;13:1234–41.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Bridgewater J, Galle PR, Khan SA, et al. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol. 2014;60:1268–89.

    Article  PubMed  Google Scholar 

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Acknowledgements

This study was supported by Intrahepatic Cholangiocarcinoma Clinical Cohort Research Program, National Key Research on Precision Medicine of China (2017YFC0908102), National Natural Science Foundation of China (81772507), and Technological Innovation and Action Project of the Shanghai Science and Technology Commission (15411950401).

Author information

Author notes

  1. Seogsong Jeong, Guijuan Luo, Zhi-Heng Wang, Meng Sha contributed equally to this work.

Authors and Affiliations

  1. Department of Liver Surgery, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai, 200127, People’s Republic of China

    Seogsong Jeong, Meng Sha & Qiang Xia

  2. International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, 225 Changhai Road, Shanghai, 200438, People’s Republic of China

    Seogsong Jeong, Guijuan Luo & Lei Chen

  3. National Center for Liver Cancer, Shanghai, 201805, People’s Republic of China

    Seogsong Jeong & Guijuan Luo

  4. The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, People’s Republic of China

    Zhi-Heng Wang

  5. Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, People’s Republic of China

    Lei Chen

Authors
  1. Seogsong Jeong
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  2. Guijuan Luo
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  3. Zhi-Heng Wang
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  4. Meng Sha
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  5. Lei Chen
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  6. Qiang Xia
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Contributions

All authors: Study concept and design; drafting of the manuscript; acquisition of data; analysis and interpretation of data. SJ, LC, QX: Critical revision of the manuscript for important intellectual content.

Corresponding authors

Correspondence to Lei Chen or Qiang Xia.

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Conflict of interest

Seogsong Jeong, Guijuan Luo, Zhi-Heng Wang, Meng Sha, Lei Chen and Qiang Xia declare no conflict of interest.

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Jeong, S., Luo, G., Wang, ZH. et al. Impact of viral hepatitis B status on outcomes of intrahepatic cholangiocarcinoma: a meta-analysis. Hepatol Int 12, 330–338 (2018). https://doi.org/10.1007/s12072-018-9881-y

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  • DOI: https://doi.org/10.1007/s12072-018-9881-y

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