Skip to main content
Log in

Haplotype combination of the bovine PCSK1 gene sequence variants and association with growth traits in Jiaxian cattle

  • Online Resources
  • Published:
Journal of Genetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1
Figure 2

References

  • Bansal A., van den Boom D., and Kammerer S. 2002 Association testing by DNA pooling: an effective initial screen. Proc. Natl. Acad. Sci. USA 99, 16871–16874.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barrett J. C., Fry B., Maller J. and Daly M. J. 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263–265.

  • Benzinou M., Creemers J. W., Choquet H., Lobbens S., Dina C., Durand E., et al. 2008 Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat. Genet. 40, 943–945.

    Article  CAS  PubMed  Google Scholar 

  • Chang Y. C., Chiu Y. F., Shih K. C., Lin M. W., Sheu W. H., Donlon T., et al. 2010 Common PCSK1 haplotypes are associated with obesity in the Chinese population. Obesity (Silver Spring) 18, 1404–1409.

    Article  CAS  Google Scholar 

  • Clark R. M., Linton E., Messing J., and Doebley J. F. 2004 Pattern of diversity in the genomic region near the maize domestication gene tb1. Proc. Natl. Acad. Sci. USA 101, 700–707.

    Article  CAS  PubMed  Google Scholar 

  • Dong W., Seidel B., Marcinkiewicz M., Chrétien M., Seidah N. G., and Day R. 1997 Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids. J. Neurosci. 17, 563–575.

    CAS  PubMed  Google Scholar 

  • Farooqi I. S., Volders K., Stanhope R., Heuschkel R., White A., Lank E., et al. 2007 Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3. J. Clin. Endocrinol. Metab. 92, 3369–3373.

    Article  CAS  PubMed  Google Scholar 

  • Jackson R. S., Creemers J. W., Ohaqi S., Raffin-Sanson M. L., Sanders L., Montaque C. T., et al. 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat. Genet. 16, 303–306.

  • Jackson R. S., Creemers J. W., Farooqi I. S., Raffin-Sanson M. L., Varro A., Dockray G. J. et al. 2003 Small intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J. Clin. Invest. 112, 1550–1560.

  • Kilpelainen T. O., Bingham S. A., Khaw K. T., Wareham N. J., and Loos R. J. 2009 Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study. Hum. Mol. Genet. 18, 3496–3501.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lloyd D. J., Bohan S., and Gekakis N. 2006 Obesity, hyperphagia and increased metabolic efficiency in PC1 mutant mice. Hum. Mol. Genet. 15, 1884–1893.

    Article  CAS  PubMed  Google Scholar 

  • Mbikay M., Croissandeau G., Sirois F., Anini Y., Mayne J., Seidah N. G. et al. 2007 A targeted deletion/insertion in the mouse PCSK1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat. Dev. Biol. 306, 584–598.

  • Qi Q., Li H., Loos R. J., Liu C., Hu F. B., Wu H., et al. 2010 Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. PLoS One 5, e10590.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ramachandrappa S. and Farooqi I. S. 2011 Genetic approaches to understanding human obesity. J. Clin. Invest. 121, 2080–2086.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sambrook J. and Russell D. W. 2001 Molecular cloning: a laboratory manual 3rd edition, vol. 3. Cold Spring Harbor Laboratory Press, New York, USA.

    Google Scholar 

  • Saunders M. A., Slatkin M., Garner C., Hammer M. F., and Nachman M. W. 2005 The extent of linkage disequilibrium caused by selection on G6PD in humans. Genetics 171, 1219–1229.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wynne K., Stanley S., McGowan B., and Bloom S. 2005 Appetite control. J. Endocrinol. 184, 291–318.

    Article  CAS  PubMed  Google Scholar 

  • Zhu X., Zhou A., Dey A., Norrbom C., Carroll R., Zhang C., et al. 2002 Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc. Natl. Acad. Sci. USA 99, 10293–10298.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This study was supported by the National Natural Science Foundation of China (grant no. 31272408), National 863 Programme of China (grant no. 2013AA102505), Agricultural Science and Technology Innovation Projects of Shaanxi Province (no. 2012NKC01-13) and Programme of National Beef Cattle Industrial Technology System (CARS-38).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to HONG CHEN.

Additional information

[Sun J., Shan L., Zhang C. and Chen H. 2014 Haplotype combination of the bovine PCSK1 gene sequence variants and association with growth traits in Jiaxian cattle. J. Genet. 93, e123–e129. Online only: http://www.ias.ac.in/jgenet/OnlineResources/93/e123.pdf]

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

SUN, J., SHAN, L., ZHANG, C. et al. Haplotype combination of the bovine PCSK1 gene sequence variants and association with growth traits in Jiaxian cattle. J Genet 94 (Suppl 1), 123–129 (2015). https://doi.org/10.1007/s12041-014-0440-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12041-014-0440-6

Keywords

Navigation