Abstract
An improved green route has been developed for the oxidation of sulfide compounds. Albendazole is converted to ricobendazole or albendazole sulfone using H 2 O 2 as an oxidant and H 2O as the solvent. High yields of the corresponding products were obtained by carrying out the reaction at room temperature. This synthetic method is environmentally clean and safe, operationally simple for the oxidation of other benzimidazole anthelmintics and various sulfide compounds.
Using H2O2 as an oxidant and H2O as the solvent, albendazole is oxidized to ricobendazole and albendazole sulfone.
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Financial support from UGC, India for a research fellowship under BSR-SAP scheme is gratefully acknowledged.
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WAGH, R.B., GUND, S.H. & NAGARKAR, J.M. An eco-friendly oxidation of sulfide compounds. J Chem Sci 128, 1321–1325 (2016). https://doi.org/10.1007/s12039-016-1121-1
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DOI: https://doi.org/10.1007/s12039-016-1121-1