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Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

Molecular Neurobiology Aims and scope Submit manuscript

Abstract

Exosomes have emerged as prominent mediators of neurodegenerative diseases where they have been shown to carry disease particles such as beta amyloid and prions from their cells of origin to other cells. Their simple structure and ability to cross the blood–brain barrier allow great opportunity to design a “makeup” with drugs and genetic elements, such as siRNA or miRNA, and use them as delivery vehicles for neurotherapeutics. Their role in neuroprotection is evident by the fact that they are involved in the regeneration of peripheral nerves and repair of neuronal injuries. This review is focused on the role of exosomes in mediating neurodegeneration and neuroprotection.

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Acknowledgments

This work was supported by the NIH grant HL-107640 to NT.

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The authors confirm that there are no conflicts of interest.

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Correspondence to Neetu Tyagi.

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Kalani, A., Tyagi, A. & Tyagi, N. Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics. Mol Neurobiol 49, 590–600 (2014). https://doi.org/10.1007/s12035-013-8544-1

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