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Clinical and Histopathologic Correlates and Management Strategies for Inflammatory Myofibroblastic tumor of the lung. A case series and review of the literature

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Abstract

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm that may arise in soft tissues of nearly every organ. Although IMTs are the most common lung tumors in pediatric populations, these tumors are extremely rare in adults, constituting less than 1% of adult lung tumors. IMTs are characterized by proliferating spindle cells with variable inflammatory component. The biological behavior of lung IMTs in adults is highly unpredictable, which confounds diagnosis and treatment. We retrospectively investigated patients with pulmonary lesions and the histopathologic diagnosis of inflammatory myofibroblastic tumor or its synonymous names (Plasma Cell Granuloma, xanthogranuloma, inflammatory pseudotumor, fibroxanthoma, and fibrous histiocytoma) at the MD Anderson Cancer Institute in the period between August 2000 and August 2016. We describe 7 adult cases of IMT of the lung that were diagnosed at MD Anderson Cancer Center. These cases highlight the tumor’s variability in terms of clinical presentation, histopathology, and biologic behavior, and underscore the challenges in the management of these rare lung neoplasms.

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Authors and Affiliations

  1. Department of Pulmonary Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA

    Ala Eddin S. Sagar

  2. Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA

    Carlos A. Jimenez & Vickie R. Shannon

Authors
  1. Ala Eddin S. Sagar
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  2. Carlos A. Jimenez
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  3. Vickie R. Shannon
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Contributions

ASS, CAJ, VRS are responsible for the conception and design, acquisition of radiological data, drafting the article, critical revision of intellectual content, and final approval of the version to be published.

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Correspondence to Ala Eddin S. Sagar.

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All authors state that they have no conflicts of interest to declare.

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This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Given the retrospective nature of this review, we were not able to reach some of the patients for an informed consent, however, the patients listed in the manuscript are completely anonymous and there were no patient identifiers included in the manuscript.

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Sagar, A.S., Jimenez, C.A. & Shannon, V.R. Clinical and Histopathologic Correlates and Management Strategies for Inflammatory Myofibroblastic tumor of the lung. A case series and review of the literature. Med Oncol 35, 102 (2018). https://doi.org/10.1007/s12032-018-1161-0

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