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Overexpression of phosphorylated 4E-binding protein 1 predicts lymph node metastasis and poor prognosis of Chinese patients with hilar cholangiocarcinoma

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Abstract

Previous studies have confirmed the role of phosphorylated form of 4E-binding protein 1 (p-4E-BP1) as a good candidate tumor biomarker. The aim of this study was to investigate p-4E-BP1 expression status in hilar cholangiocarcinoma (HCCA) specimens and to clarify its clinical significance. Tissue microarray containing tumor specimens obtained from 61 patients with HCCA were constructed. p-4E-BP1 was investigated by immunohistochemical studies. High/moderate expression p-4E-BP1 was observed in 57.4 % (35/61) primary cancer specimens. Overexpression of p-4E-BP1 protein was associated with poor differentiation and regional lymph node metastasis. Survival analysis and Cox proportional hazards model revealed that p-4E-BP1 overexpression was an independent factor in predicting recurrence-free survival and overall survival for HCCA patients, apart from tumor invasion and complete resection. P-4E-BP1 was highly expressed in HCCA. Overexpressed p-4E-BP1 might be a novel biomarker to predict the clinical outcome of patients with resected HCCA.

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Acknowledgments

We are grateful for the participation of outpatients and healthy donors, without which our study would not have been possible. The valuable help from the Departments of Pathology of 101th Hospital of People’s Liberation Army is also greatly appreciated.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of General Surgery, 101st Hospital of People’s Liberation Army, Wuxi, Jiangsu, China

    Zheng Fang, Zhiqiang Tian & Kunlun Luo

  2. Department of Oncological Surgery, 81st Hospital of People’s Liberation Army, Nanjing, Jiangsu, China

    Lei Lu

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  1. Zheng Fang
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  2. Lei Lu
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  4. Kunlun Luo
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Correspondence to Zheng Fang.

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Zheng Fang and Lei Lu have contributed equally in this work.

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Fang, Z., Lu, L., Tian, Z. et al. Overexpression of phosphorylated 4E-binding protein 1 predicts lymph node metastasis and poor prognosis of Chinese patients with hilar cholangiocarcinoma. Med Oncol 31, 940 (2014). https://doi.org/10.1007/s12032-014-0940-5

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  • DOI: https://doi.org/10.1007/s12032-014-0940-5

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