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Polymorphic CT dinucleotide repeat in the GATA3 gene and risk of breast cancer in Iranian women

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Abstract

GATA3 is an enriched transcription factor in mammary epithelium. To date, there has been no study on the relationship between microsatellites in the GATA3 gene and breast cancer risk. In this study, we investigated the existence of polymorphisms in the cytosine–thymine (CT) dinucleotide repeat in intron 3 of the GATA3 gene and its association with breast cancer risk. A case–control study of 206 breast cancer patients and 262 controls was conducted in Iranian women. Several different CT repeat alleles of GATA3 were detected in both the patients and controls. The frequencies of 17 and 18 alleles in patients were significantly lower than controls. Our findings demonstrate that women who carry 17-CT (OR = 0.5; p = 0.003) or 18-CT (OR = 0.41, p = 0.02) alleles of GATA3 gene are at lower risk of developing breast cancer. The highest protection against breast cancer was observed with heterozygotes of 16/17 repeats (OR = 0.12, p = 0.02). Also, the presence of the 17-CT allele has a positive relation with estrogen receptor expression. However, we found that the allelic length of GATA3 polymorphisms had no significant effect on the age onset or grade of the disease, as well as the expression of progesterone receptors and HER2.

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Acknowledgments

The authors wish to thank all patients who contributed to this investigation and Professor Farzin Farzaneh (Kings College London) and Valerie Crolley for valuable suggestions and critical reading of this manuscript. This work was supported by University of Isfahan.

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Authors and Affiliations

  1. Department of Biology, Faculty of Sciences, University of Isfahan, Hezar-Jarib, Isfahan, Iran

    Aghaabdollahian Zakieh, Safari Forousan & Tavassoli Manoochehr

  2. Division of Oncology, Medical Sciences University of Isfahan, Isfahan, Iran

    Hematti Simin

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  1. Aghaabdollahian Zakieh
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  2. Hematti Simin
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  3. Safari Forousan
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  4. Tavassoli Manoochehr
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Correspondence to Tavassoli Manoochehr.

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Zakieh, A., Simin, H., Forousan, S. et al. Polymorphic CT dinucleotide repeat in the GATA3 gene and risk of breast cancer in Iranian women. Med Oncol 30, 504 (2013). https://doi.org/10.1007/s12032-013-0504-0

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  • DOI: https://doi.org/10.1007/s12032-013-0504-0

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