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Scrotal Pain and Ulceration Post HIPEC: A Case Report

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Fig. 1
Fig. 2

Abbreviations

CRS:

Cytoreductive surgery

HIPEC:

Hyperthermic intraperitoneal chemotherapy

MMC:

Mitomycin C

PPV:

Patent processus vaginalis

DMSO:

Dimethylsulfoxide

References

  1. Sugarbaker PH. Management of peritoneal-surface malignancy: the surgeon’s role. Langenbeck’s Arch Surg. 1999;384(6):576–87.

    Article  CAS  Google Scholar 

  2. Sugarbaker PH. Cytoreductive surgery and peri-operative intraperitoneal chemotherapy as a curative approach to pseudomyxoma peritonei syndrome. Eur J Surg Oncol. 2001;27(3):239–43.

    Article  CAS  PubMed  Google Scholar 

  3. Smeenk RM, Verwaal VJ, Antonini N, Zoetmulder FA. Survival analysis of pseudomyxoma peritonei patients treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg. 2007;245(1):104–9.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Sugarbaker PH, Mora JT, Carmignani P, Stuart OA, Yoo D. Update on chemotherapeutic agents utilized for perioperative intraperitoneal chemotherapy. Oncologist. 2005;10(2):112–22.

    Article  CAS  PubMed  Google Scholar 

  5. Bijelic L, Jonson A, Sugarbaker PH. Systematic review of cytoreductive surgery and heated intraoperative intraperitoneal chemotherapy for treatment of peritoneal carcinomatosis in primary and recurrent ovarian cancer. Ann Oncol. 2007;18(12):1943–50.

    Article  CAS  PubMed  Google Scholar 

  6. Roviello F, Pinto E, Corso G, Pedrazzani C, Caruso S, Filippeschi M, et al. Safety and potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal carcinomatosis from primary or recurrent ovarian cancer. J Surg Oncol. 2010;102(6):663–70. doi:10.1002/jso.21682.

    Article  PubMed  Google Scholar 

  7. Kitayama J. Intraperitoneal chemotherapy against peritoneal carcinomatosis: current status and future perspective. Surg Oncol. 2014;23(2):99–106. doi:10.1016/j.suronc.2014.03.004.

    Article  PubMed  Google Scholar 

  8. Lambert LA, Armstrong TS, Lee JJ, Liu S, Katz MH, Eng C, et al. Incidence, risk factors, and impact of severe neutropenia after hyperthermic intraperitoneal mitomycin C. Ann Surg Oncol. 2009;16(8):2181–7. doi:10.1245/s10434-009-0523-4.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Hadi R, Saunders V, Utkina O, Clingan P, Kam P, Links M, et al. Review of patients with peritoneal malignancy treated with peritonectomy and heated intraperitoneal chemotherapy. ANZ J Surg. 2006;76(3):156–61.

    Article  PubMed  Google Scholar 

  10. Stephens AD, Alderman R, Chang D, Edwards GD, Esquivel J, Sebbag G, et al. Morbidity and mortality of 200 treatments with cytoreductive surgery and heated intraoperative intraperitoneal chemotherapy using the coliseum technique. Ann Surg Oncol. 1999;6(8):790–6.

    Article  CAS  PubMed  Google Scholar 

  11. Glehen O, Osinsky D, Cotte E, Kwiatkowski F, Freyer G, Isaac S, et al. Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive patients. Ann Surg Oncol. 2003;10(8):863–9.

    Article  CAS  PubMed  Google Scholar 

  12. Haslinger M, Francescutti V, Attwood K, McCart JA, Fakih M, Kane 3rd JM, et al. A contemporary analysis of morbidity and outcomes in cytoreduction/hyperthermic intraperitoneal chemoperfusion. Cancer Med. 2013;2(3):334–42. doi:10.1002/cam4.80.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Teo MC, Tan GH, Tham CK, Lim C, Soo KC. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in Asian patients: 100 consecutive patients in a single institution. Ann Surg Oncol. 2013;20(9):2968–74. doi:10.1245/s10434-013-2947-0.

    Article  PubMed  Google Scholar 

  14. Akhavan A, Yin M, Benoit R. Scrotal ulcer after intraperitoneal hyperthermic chemotherapy. Urology. 2007;69(4):778.e9–10.

    Article  Google Scholar 

  15. Silva F, Avancini J, Criado P, Pfiffer T, Lobo A, Sanches J. Scrotal ulcer developed after intraperitoneal hyperthermic chemotherapy with mitomycin-C. BJU Int. 2012. doi:10.1002/BJUIw-2012-019-web.

    PubMed  Google Scholar 

  16. Rahman N, Lakhoo K. Patent processus vaginalis: a window to the abdomen. Afr J Paediatr Surg. 2009;6(2):116–7. doi:10.4103/0189-6725.54778.

    Article  CAS  PubMed  Google Scholar 

  17. Mandel P, Faegenburg D, Imbriano LJ. The use of technetium-99 m sulfur colloid in the detection of patent processus vaginalis in patients on continuous ambulatory peritoneal dialysis. Clin Nucl Med. 1985;10(8):553–5.

    Article  CAS  PubMed  Google Scholar 

  18. Schrijvers DL. Extravasation: a dreaded complication of chemotherapy. Ann Oncol. 2003;14 Suppl 3:iii26–30.

    PubMed  Google Scholar 

  19. Lee DH, Jung HB, Chung MS, Lee SH, Chung BH. Patent processus vaginalis in adults who underwent robot-assisted laparoscopic radical prostatectomy: predictive signs of postoperative inguinal hernia in the internal inguinal floor. Int J Urol. 2013;20(2):177–82. doi:10.1111/j.1442-2042.2012.03118.x.

    Article  CAS  PubMed  Google Scholar 

  20. Lee DH, Koo KC, Lee SH, Chung BH. A simple procedure to prevent postoperative inguinal hernia after robot-assisted laparoscopic radical prostatectomy: a plugging method of the internal inguinal floor for patients with patent processus vaginalis. J Urol. 2014;191(2):468–72. doi:10.1016/j.juro.2013.09.035.

    Article  PubMed  Google Scholar 

  21. Scuderi N, Onesti MG. Antitumor agents: extravasation, management, and surgical treatment. Ann Plast Surg. 1994;32(1):39–44.

    Article  CAS  PubMed  Google Scholar 

  22. Bertelli G. Prevention and management of extravasation of cytotoxic drugs. Drug Saf. 1995;12(4):245–55.

    Article  CAS  PubMed  Google Scholar 

  23. Alberts DS, Dorr RT. Case report: topical DMSO for mitomycin C-induced skin ulceration. Oncol Nurs Forum. 1991;18(4):693–5.

    CAS  PubMed  Google Scholar 

  24. Ludwig CU, Stoll HR, Obrist R, Obrecht JP. Prevention of cytotoxic drug-induced skin ulcers with dimethyl sulfoxide and α-tocopherole. Eur J Cancer Clin Oncol. 1987;23(3):327–9.

    Article  CAS  PubMed  Google Scholar 

  25. Rentschler R, Wilbur D. Pyridoxine: a potential local antidote for mitomycin-C extravasation. J Surg Oncol. 1988;37(4):269–71.

    Article  CAS  PubMed  Google Scholar 

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Surgical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore

    Nazirul Hannan B. Abdul Aziz, Weining Wang & Melissa Ching Ching Teo

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  1. Nazirul Hannan B. Abdul Aziz
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  2. Weining Wang
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  3. Melissa Ching Ching Teo
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Correspondence to Melissa Ching Ching Teo.

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Abdul Aziz, N.H.B., Wang, W. & Teo, M.C.C. Scrotal Pain and Ulceration Post HIPEC: A Case Report. J Gastrointest Canc 46, 60–63 (2015). https://doi.org/10.1007/s12029-014-9665-0

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  • DOI: https://doi.org/10.1007/s12029-014-9665-0

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