Abstract
Purpose
The incidence of anal cancer is increasing, particularly among HIV and men who have sex with men (MSM) groups. The vast majority of cases are associated with human papillomavirus (HPV), the most common sexually transmitted infection. Epidemiological studies have also documented low survival, which might be linked to lack of appropriate screening, access, and utilization of pertinent health care services. Our objective was to assess the relative survival (1 and 3 years) of anal cancer in Puerto Rico for men and women during the period from 2000–2007.
Methods
All histological types of cancer of anus, anal canal, and anorectum (ICD-O-3 codes C210-C218), except for sarcomas, were included. Relative survival was estimated with the use of life tables from the population of Puerto Rico. In addition, the excess survival was compared by age at diagnosis, histology, and stage (defined as local, regional, or distant), using the Poisson regression model.
Results
The overall 3-year relative survival in Puerto Rico was the same (53 %) for men and women.
Conclusions
Our findings establish baseline survival data for anal cancer in Hispanics from Puerto Rico. Since now, the national guidelines for anal cancer screening and treatment are on their way to be determined; baseline information about survival will allow monitoring the efficacy that standardized screening programs may eventually have in increasing anal cancer survival in this population.
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References
de Pokomandy A, Rouleau D, Ghattas G, Vézina S, Coté P, Macleod J, et al. Prevalence, clearance, and incidence of anal human papillomavirus infection in HIV-infected men: the HIPVIRG cohort study. J Infect Dis. 2009;199(7):965–73.
Joseph DA, Miller JW, Wu X, Chen VW, Morris CR, Goodman MT, et al. Understanding the burden of human papillomavirus-associated anal cancers in the US. Cancer. 2008;113(10 Suppl):2892–900.
Palefsky JM, Holly EA, Efirdc JT, Da Costa M, Jay N, Berry JM, et al. Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS. 2005;19(13):1407–14.
Ortiz AP, Soto-Salgado M, Suárez E, del Carmen S-OM, Tortolero-Luna G, Pérez CM. Sexual behaviors among adults in Puerto Rico: a population-based study. J Sex Med. 2011;8(9):2439–49.
Leichliter JS, Chandra A, Liddon N, Fenton KA, Aral SO. Prevalence and correlates of heterosexual anal and oral sex in adolescents and adults in the United States. J Infect Dis. 2007;196(12):1852.
Colón-López V, Rodríguez-Díaz CE, Ortiz AP, Soto-Salgado M, Suárez E, Pérez CM. HIV-related risk behaviors among a sample of men who have sex with men in Puerto Rico: an overview of substance use and sexual practices. P R Health Sci J. 2011;30(2):65–8.
Johnson LG, Madeleine MM, Newcomer LM, Schwartz SM, Daling JR. Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973–2000. Cancer. 2004;101(2):281–8.
US Census Bureau. Percent Change. Available at: http://www.census.gov/acs/www/Downloads/data_documentation/Accuracy/PercChg.pdf. Accessed 17 September 2013.
Dickman P, Coviello E, Hills M. Estimating and modelling relative survival. The Stata Journal [Internet]. [cite 7 June 2012]; Number ii, pp. 1–24. Available at: http://www.pauldickman.com/survival/strs.pdf. Accessed 28 November 2013.
SEER Cancer Statistics Factsheets: Anal Cancer. National Cancer Institute. Bethesda, MD. Available at: http://seer.cancer.gov/statfacts/html/anus.html Accessed 4 December 2013.
Madeline MM, Newcomer LM. Cancer of the anus. SEER Survival Monograph. National Cancer Institute. Available at: http://seer.cancer.gov/publications/survival/surv_anus.pdf. Accessed April, 2012
Ortiz AP, Soto-Salgado M, Calo W, et al. Disparities in breast cancer in Puerto Rico and among Hispanics, non-Hispanic whites, and non-Hispanics blacks in the United States, 1992–2004. Breast J. 2010;16:666–8.
IOM (Institute of Medicine). The Health of lesbian, gay, bisexual, and transgender people: building a foundation for better understanding. Washington, DC: The National Academies Press; 2011.
Palefsky JM, Giuliano AR, Goldstone S, Moreira Jr ED, Aranda C, Jessen H, et al. HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. N Engl J Med. 2011;365(17):1576–85.
Acknowledgements
The authors wish to acknowledge the collaboration of the Puerto Rico Central Cancer Registry personnel as well as graduate students from the University of Puerto Rico, Medical Sciences Campus Carola, T. Sánchez Díaz and Hilmaris Centeno Girona. The study describe above was supported by U54CA96297 and U54CA96300 from the UPR/MDACC Partnership for Excellence in Cancer Research, NCI; by 5U58-DP003863-02 from the CDC/National Program Cancer Registries; and by R03 DA027939-01 from NIDA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCI.
Ethical Standards
This study was previously approved by University of Puerto Rico Medical Sciences Campus (UPRMSC) Institutional Review Board (IRB).
Conflict of Interest
The authors declare that they have no conflict of interest.
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Colon-Lopez, V., Ortiz, A.P., Soto-Salgado, M. et al. Survival from Anal Cancer Among Hispanics—Puerto Rico, 2000–2007. J Gastrointest Canc 45, 234–238 (2014). https://doi.org/10.1007/s12029-014-9607-x
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DOI: https://doi.org/10.1007/s12029-014-9607-x