Abstract
Background
“Bath salts” or synthetic cathinone toxicity remains a potentially deadly clinical condition. We report a delayed leukoencephalopathy with persistent minimally conscious state.
Methods
Case report.
Results
A 36-year-old man presents with delayed encephalopathy, dysautonomia, fulminant hepatic failure, and renal failure from severe rhabdomyolysis after consuming bath salts. MRI showed diffusion restriction in the splenium of the corpus callosum and subcortical white matter.
Conclusions
The combination of acute leukoencephalopathy, rhabdomyolysis and fulminant hepatic failure may point to bath salt inhalation and should be known to neurointensivists.
Similar content being viewed by others
References
Ross EA, Reisfield GM, Watson MC, Chronister CW, Goldberger BA. Psychoactive “bath salts” intoxication with methylenedioxypyrovalerone. Am J Med. 2012;125:854–8.
Baumann MH, Partilla JS, Lehner KR. Psychoactive “bath salts”: not so soothing. Eur J Pharm. 2013;698:1–5.
German CL, Fleckenstein AE, Hanson GR. Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sci. 2014;97:2–8.
Coppola M, Mondola R. Synthetic cathinones: chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as “bath salts” or “plant food”. Toxicol Lett. 2012;211:144–9.
Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol. 2012;8:33–42.
Ross EA, Watson M, Goldberger B. “Bath salts” intoxication. N Engl J Med. 2011;365:967–8.
Boshuisen K, Arends JE, Rutgers DR, Frijns CJM. A young man with hemiplegia after inhaling the bath salt “ivory wave”. Neurology. 2012;78:1533–4.
Hadlock GC, Webb KM, McFadden LM, Chu PW, Ellis JD, Allen SC, et al. 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. J Pharmacol Exp Ther. 2011;339:530–6.
Borek HA, Holstege CP. Hyperthermia and multiorgan failure after abuse of “bath salts” containing 3,4-methylenedioxypyrovalerone. Ann Emerg Med. 2012;60:103–5.
Sammler EM, Foley PL, Lauder GD, Wilson SJ, Goudie AR, O’Riordan J. A harmless high? Lancet. 2010;376:742.
Richards JR. Rhabdomyolysis and drugs of abuse. J Emerg Med. 2000;19(1):51–6.
O’Connor AD, Padilla-Jones A, Gerkin RD, Levine M. Precalence of rhabdomyolysis in sympathomimetic toxicity: a comparison of stimulants. J Med Toxicol. 2015;11:195–200.
Nakagawa Y, Suzuki T, Tayama S, Ishii H, Ogata A. Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes. Arch Toxicol. 2009;83(1):69–80.
Mitzner SR. Extracorporeal liver support-albumin dialysis with the molecular adsorbent recirculating system (MARS). Ann Hepatol. 2011;10(Suppl 1):S21–8.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kramer, C.L., Wetzel, D.R. & Wijdicks, E.F.M. Devastating Delayed Leukoencephalopathy Associated with Bath Salt Inhalation. Neurocrit Care 24, 454–458 (2016). https://doi.org/10.1007/s12028-015-0226-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12028-015-0226-6