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The sera from adult patients with suggestive signs of autoimmune diseases present antinuclear autoantibodies that cross-react with Leishmania infantum conserved proteins: Crude Leishmania histone and Soluble Leishmnia antigens

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An Erratum to this article was published on 21 February 2015

Abstract

Visceral leishmaniasis has been associated with hyper-gammaglobulinemia and antinuclear antibodies and may simulate systemic lupus erythematosus. Sera from patients with visceral leishmaniasis have been shown to strongly react against conserved proteins from the parasite, such as ribosomal and histones. Some of these proteins have also been described as immunogenic in several auto-immune syndromes, and the detection of antibodies against them is considered to be indicative of disorder in the immune system. This study aimed to assess by enzyme-linked immunosorbent assay, test routinely employed in visceral leishmaniasis diagnosis, the recognition of Crude Leishmania histone and Soluble Leishmania antigens proteins from Leishmania infantum by adult patients with suggestive signs of autoimmune diseases. Our results show that the humoral response generated during autoimmune diseases cross-reacts with the parasitic Crude Leishmania histone and Soluble Leishmania antigens. In these cases, higher precautions must be taken to confirm the presence of visceral leishmaniasis in front of positive serology in antinuclear antibodies positive sera, in order to avoid wrong diagnosis.

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Acknowledgments

We would like to thank Dr. Steven G. Reed, Infectious Disease Research Institute (IDRI), Seattle, WA, for providing recombinant K39 of L. infantum and Dr. Randy Howard (IDRI), for his critical reading of the manuscript. The authors would like also to thank Dr. Jihene Bettaieb, Pasteur Institute of Tunis, Tunisia, for her statistical analysis support.

Conflict of interest

The authors declare that there are no financial, personal, or professional competing interests that may interfere with this work.

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Authors and Affiliations

  1. Research Laboratory of Medical Parasitology, Biotechnology and Biomolecules, LR 11 IPT06, Pasteur Institute of Tunis, 13, Place Pasteur, B.P. 74, 1002, Tunis, Belvédère, Tunisia

    Sami Lakhal, Meriem Benabid, Ines Ben Sghaier, Aïda Bouratbine & Yousr Galai

  2. Laboratory of Clinical Immunology, Pasteur Institute of Tunis, 13, Place Pasteur, B.P. 74, 1002, Tunis, Belvédère, Tunisia

    Yousr Galai

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  1. Sami Lakhal
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  2. Meriem Benabid
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Correspondence to Sami Lakhal.

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Lakhal, S., Benabid, M., Sghaier, I.B. et al. The sera from adult patients with suggestive signs of autoimmune diseases present antinuclear autoantibodies that cross-react with Leishmania infantum conserved proteins: Crude Leishmania histone and Soluble Leishmnia antigens. Immunol Res 61, 154–159 (2015). https://doi.org/10.1007/s12026-014-8589-x

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