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Pathology of Struma Ovarii: A Report of 96 Cases

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Abstract

Thyroid tissue is a relatively frequent component of mature teratoma and can occur in 5–20 % of cases. Struma ovarii is defined as ovarian goiter which comprises either entirely or predominantly thyroid tissue (>50 %). This also includes cases of mature teratoma with less than 50 % thyroid tissue but harboring thyroid-associated malignancy. A total of 118 patients with mature teratoma containing thyroid tissue were identified at our institution (1989 to 2014). Ninety-six cases were diagnosed struma ovarii, including 10 cases of papillary thyroid carcinoma, 1 case of highly differentiated follicular carcinoma of ovarian origin (HDFCO), 5 cases of strumal carcinoid, and 80 cases of struma ovarii (53 cases of thyroid-only struma ovarii). Six cases had diffuse adenomatous hyperplasia, and seven cases had focal adenomatous hyperplasia. There was no recurrence on follow-up except one of the papillary thyroid carcinomas. Concurrent primary ovarian lesions included: serous cystadenoma—3, mucinous cystadenoma—4, Brenner tumor—3, thecoma—2, ovarian fibroma—1, and focal hilus cell hyperplasia—4 cases. In this series, papillary thyroid carcinoma and strumal carcinoid were the most common well-differentiated neoplasm/malignancies arising in struma ovarii; these demonstrate a minimal or no aggressive clinical behavior.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA

    Shuanzeng Wei, Zubair W. Baloch & Virginia A. LiVolsi

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  1. Shuanzeng Wei
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  2. Zubair W. Baloch
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  3. Virginia A. LiVolsi
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Correspondence to Shuanzeng Wei.

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Wei, S., Baloch, Z.W. & LiVolsi, V.A. Pathology of Struma Ovarii: A Report of 96 Cases. Endocr Pathol 26, 342–348 (2015). https://doi.org/10.1007/s12022-015-9396-1

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  • DOI: https://doi.org/10.1007/s12022-015-9396-1

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