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Pituitary Adenoma with Mucin Cells in a Man with an Unusual Presentation of Carney Complex

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Abstract

We describe a 44-year-old man with infertility, acromegaly, and hypergonadotropic hypogonadism. Clinical examination of the patient revealed hyperpigmented macules on the lips, buccal mucosa, and face which were histologically confirmed as cutaneous myxomas and blue nevi. Ultrasound revealed testicular calcifications and multiple hypoechoic thyroid nodules. MR imaging showed a pituitary microadenoma and resection revealed it to be a growth hormone and prolactin-secreting adenoma with the unusual finding of admixed individual mucin-producing cells. We discuss mucin cells in pituitary adenoma, an unreported pathologic finding in a patient with Carney complex.

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Acknowledgments

The authors would like to thank Stephen J. Coleman, Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, for his technical assistance and providing the electron microscopy images.

Conflict of Interest

The authors have no commercial associations or other conflicts of interest to disclose in connection with the submitted manuscript. The information in this manuscript is not funded.

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Authors and Affiliations

  1. Departments of Pathology and Laboratory Medicine and Ophthalmology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 626, Rochester, NY, 14642, USA

    Gabrielle A. Yeaney

  2. Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA

    Jillene M. Brathwaite & Laura M. Calvi

  3. Department of Neurosurgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA

    Matthew L. Dashnaw & G. Edward Vates

Authors
  1. Gabrielle A. Yeaney
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  2. Jillene M. Brathwaite
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  3. Matthew L. Dashnaw
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  4. G. Edward Vates
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  5. Laura M. Calvi
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Corresponding author

Correspondence to Gabrielle A. Yeaney.

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Yeaney, G.A., Brathwaite, J.M., Dashnaw, M.L. et al. Pituitary Adenoma with Mucin Cells in a Man with an Unusual Presentation of Carney Complex. Endocr Pathol 24, 106–109 (2013). https://doi.org/10.1007/s12022-013-9247-x

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  • DOI: https://doi.org/10.1007/s12022-013-9247-x

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