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Dysregulated expression of long noncoding RNAs serves as diagnostic biomarkers of type 2 diabetes mellitus

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A Correction to this article was published on 20 August 2019

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Abstract

Purpose

Long noncoding RNAs (LncRNAs) are widely investigated in various diseases as a novel type of biomarkers. We aimed to elucidate the diagnostic values of lncRNAs in patients with type 2 diabetes mellitus (T2DM).

Methods

We comprehensively searched PubMed, Web of Science, EMBASE, CBM, Scopus, and the Cochrane Library databases from the inception to 3 January 2019. Studies concerning the association between lncRNAs expression and diagnostic outcomes in type 2 diabetes mellitus patients were included. We employed pooled odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate diagnostic parameters.

Results

Seven relevant studies were eligible in our study. The pooled results showed that lncRNAs performed the area under the curve (AUC) of 0.73 (95%Cl: 0.69–0.77), with sensitivity of 0.71 (95%Cl: 0.64–0.77) and specificity of 0.66 (95%Cl: 0.60–0.71) in discriminating type 2 diabetes from healthy controls. As for prediabetes, lncRNAs conducted AUC of 0.75 with 76% sensitivity and 64% specificity. Moreover, subgroup analysis based on expression levels of lncRNAs, sample sizes, and specimen of eligible studies were further performed.

Conclusions

This study indicates that lncRNAs may serve as promising indicators for diagnostic evaluation of T2DM patients.

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Change history

  • 20 August 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Authors’ contributions

Study conception and design: Z.W.Y., Z.J. and C.L.L. Acquisition of data: Z.W.Y., Z.J., H.X. and C.L.L. Analysis of data: Z.W.Y., Z.J. Paper drafting: Z.W.Y., C.L.L. Critical appraisal of paper: C.L.L. All the authors have approved the final paper to be published.

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  1. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China

    Weiyue Zhang, Juan Zheng, Xiang Hu & Lulu Chen

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  1. Weiyue Zhang
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Correspondence to Lulu Chen.

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Zhang, W., Zheng, J., Hu, X. et al. Dysregulated expression of long noncoding RNAs serves as diagnostic biomarkers of type 2 diabetes mellitus. Endocrine 65, 494–503 (2019). https://doi.org/10.1007/s12020-019-02015-7

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