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Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus

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References

  1. M. Janghorbani, R.M. Van Dam, W.C. Willett, F.B. Hu, Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am. J. Epidemiol. 166, 495–505 (2007)

    Article  PubMed  Google Scholar 

  2. L.J. Melton 3rd, B.L. Riggs, C.L. Leibson, S.J. Achenbach, J.J. Camp, M.L. Bouxsein, E.J. Atkinson, R.A. Robb, S. Khosla, A bone structural basis for fracture risk in diabetes. J. Clin. Endocrinol. Metab. 93, 4804–4809 (2008)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. P. Vestergaard, Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes–a meta-analysis. Osteoporos. Int. 18, 427–444 (2007)

    Article  CAS  PubMed  Google Scholar 

  4. J.C. Krakauer, M.J. McKenna, N.F. Buderer, D.S. Rao, F.W. Whitehouse, A.M. Parfitt, Bone loss and bone turnover in diabetes. Diabetes 44, 775–782 (1995)

    Article  CAS  PubMed  Google Scholar 

  5. M. Yamamoto, T. Yamaguchi, K. Nawata, M. Yamauchi, T. Sugimoto, Decreased PTH levels accompanied by low bone formation are associated with vertebral fractures in postmenopausal women with type 2 diabetes. J. Clin. Endocrinol. Metab. 97, 1277–1284 (2012)

    Article  CAS  PubMed  Google Scholar 

  6. S.E. Shoelson, J. Lee, A.B. Goldfine, Inflammation and insulin resistance. J. Clin. Investig. 116, 1793–1801 (2006)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. D. Cai, M. Yuan, D.F. Frantz, P.A. Melendez, L. Hansen, J. Lee, S.E. Shoelson, Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 11, 183–190 (2005)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. M.N. Weitzmann, S. Cenci, L. Rifas, J. Haug, J. Dipersio, R. Pacifici, T cell activation induces human osteoclast formation via receptor activator of nuclear factor kappaB ligand-dependent and -independent mechanisms. J. Bone Miner. Res. 16, 328–337 (2001)

    Article  CAS  PubMed  Google Scholar 

  9. P.J. Kostenuik, V. Shalhoub, Osteoprotegerin: a physiological and pharmacological inhibitor of bone resorption. Curr. Pharm. Des. 7, 613–635 (2001)

    Article  CAS  PubMed  Google Scholar 

  10. A.B. Goldfine, V. Fonseca, K.A. Jablonski, L. Pyle, M.A. Staten, S.E. Shoelson, The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann. Intern. Med. 152, 346–357 (2010)

    Article  PubMed Central  PubMed  Google Scholar 

  11. M.J. Yin, Y. Yamamoto, R.B. Gaynor, The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396, 77–80 (1998)

    Article  CAS  PubMed  Google Scholar 

  12. A.B. Goldfine, R. Silver, W. Aldhahi, D. Cai, E. Tatro, J. Lee, S.E. Shoelson, Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin. Transl. Sci. 1, 36–43 (2008)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. J.S. Manavalan, S. Cremers, D.W. Dempster, H. Zhou, E. Dworakowski, A. Kode, S. Kousteni, M.R. Rubin, Circulating osteogenic precursor cells in type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 97, 3240–3250 (2012)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. A.G. Pittas, S.S. Harris, M. Eliades, P. Stark, B. Dawson-Hughes, Association between serum osteocalcin and markers of metabolic phenotype. J. Clin. Endocrinol. Metab. 94, 827–832 (2009)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Y. Bao, X. Ma, R. Yang, F. Wang, Y. Hao, J. Dou, H. He, W. Jia, Inverse relationship between serum osteocalcin levels and visceral fat area in Chinese men. J. Clin. Endocrinol. Metab. 98, 345–351 (2013)

    Article  CAS  PubMed  Google Scholar 

  16. S. Kiechl, J. Wittmann, A. Giaccari, M. Knoflach, P. Willeit, A. Bozec, A.R. Moschen, G. Muscogiuri, G.P. Sorice, T. Kireva, M. Summerer, S. Wirtz, J. Luther, D. Mielenz, U. Billmeier, G. Egger, A. Mayr, F. Oberhollenzer, F. Kronenberg, M. Orthofer, J.M. Penninger, J.B. Meigs, E. Bonora, H. Tilg, J. Willeit, G. Schett, Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat. Med. 19, 358–363 (2013)

    Article  CAS  PubMed  Google Scholar 

  17. N. Napoli, E. Vittinghoff, N. Pannacciulli, D. Crittenden, J. Yun, A. Wang, R. Wagman, A.V. Schwartz, Effect of denosumab on fasting glucose concentrations in postmenopausal women with osteoporosis: results from subjects with diabetes or prediabetes from the FREEDOM trial. J. Bone Miner. Res. (2014)

  18. S. Minisola, S. Dionisi, M.T. Pacitti, F. Paglia, V. Carnevale, A. Scillitani, S. Mazzaferro, G.S. De, J. Pepe, E. Derasmo, E. Romagnoli, Gender differences in serum markers of bone resorption in healthy subjects and patients with disorders affecting bone. Osteoporos. Int. 13, 171–175 (2002)

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank Drs. Bela F. Asztalos, Masumi Ai, and Ernst J. Schaefer of the Lipid Metabolism Laboratory, Tufts University, Boston, MA for measuring the adiponectin, insulin, C- peptide, and CRP. Support for this work was provided by program Grant PO50HL083813 from the National Institutes of Health.

Conflict of interest

The authors do not have any conflicts of interest.

Funding

NIH Grants RC4 DK090776, U01 DK74556, P50 HL083813, K24 DK074457 and P01 DK036836.

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Correspondence to Mishaela R. Rubin.

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For the TINSAL-T2D Study Team.

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Rubin, M.R., Goldfine, A.B., McMahon, D.J. et al. Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus. Endocrine 50, 504–507 (2015). https://doi.org/10.1007/s12020-015-0535-8

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  • DOI: https://doi.org/10.1007/s12020-015-0535-8

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