Abstract
A great number of body mass index (BMI)/obesity-related loci have been identified by recent genome-wide association studies. The objective of the study is to investigate the associations of 11 obesity-related loci with insulin resistance (IR) in a Chinese children population. Participants included 3,468 Chinese children, aged 6–18 years. The 75 percentile (equal to 2.93) of homeostasis model assessment of IR (HOMA-IR) index was considered as the cut-off of IR. A total of 868 IR cases and 2,600 control children were identified. In age- and sex-adjusted model, only two SNPs in/near GNPDA2 and KCTD15 genes were significantly associated with risk of IR [GNPDA2 rs10938397: allelic odds ratio (OR) = 1.19, 95 % confidence interval (CI) 1.06–1.34, P = 0.003; KCTD15 rs29941: allelic OR = 1.15, 95 % CI = 1.01–1.31, P = 0.034]; genetic risk score was also significantly associated risk of IR (OR = 1.08, 95 % 1.04–1.12, P = 1.18 × 10−4). After additional adjustment for BMI, none remained significant. The associations of GNPDA2 rs10938397 and the SNPs in combination with risk of IR remained statistically significant after correction for multiple testing. The present study demonstrated that the associations of GNPDA2 rs10938397 and the SNPs in combination with risk of IR were statistically significant, which were dependent on BMI.
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References
D.E. Moller, J.S. Flier, Insulin resistance-mechanisms, syndromes, and implications. N. Engl. J. Med. 325, 938–948 (1991)
T.M. Frayling, N.J. Timpson, M.N. Weedon, E. Zeggini, R.M. Freathy, C.M. Lindgren, J.R. Perry, K.S. Elliott, H. Lango, N.W. Rayner, B. Shields, L.W. Harries, J.C. Barrett, S. Ellard, C.J. Groves, B. Knight, A.M. Patch, A.R. Ness, S. Ebrahim, D.A. Lawlor, S.M. Ring, Y. Ben-Shlomo, M.R. Jarvelin, U. Sovio, A.J. Bennett, D. Melzer, L. Ferrucci, R.J. Loos, I. Barroso, N.J. Wareham, F. Karpe, K.R. Owen, L.R. Cardon, M. Walker, G.A. Hitman, C.N. Palmer, A.S. Doney, A.D. Morris, G.D. Smith, A.T. Hattersley, M.I. McCarthy, A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894 (2007)
R.J. Loos, C.M. Lindgren, S. Li, E. Wheeler, J.H. Zhao, I. Prokopenko, M. Inouye, R.M. Freathy, A.P. Attwood, J.S. Beckmann, S.I. Berndt; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, K.B. Jacobs, S.J. Chanock, R.B. Hayes, S. Bergmann, A.J. Bennett, S.A. Bingham, M. Bochud, M. Brown, S. Cauchi, J.M. Connell, C. Cooper, G.D. Smith, I. Day, C. Dina, S. De, E.T. Dermitzakis, A.S. Doney, K.S. Elliott, P. Elliott, D.M. Evans, I. Sadaf Farooqi, P. Froguel, J. Ghori, C.J. Groves, R. Gwilliam, D. Hadley, A.S. Hall, A.T. Hattersley, J. Hebebrand, I.M. Heid; KORA, C. Lamina, C. Gieger, T. Illig, T. Meitinger, H.E. Wichmann, B. Herrera, A. Hinney, S.E. Hunt, M.R. Jarvelin, T. Johnson, J.D. Jolley, F. Karpe, A. Keniry, K.T. Khaw, R.N. Luben, M. Mangino, J. Marchini, W.L. McArdle, R. McGinnis, D. Meyre, P.B. Munroe, A.D. Morris, A.R. Ness, M.J. Neville, A.C. Nica, K.K. Ong, S. O’Rahilly, K.R. Owen, C.N. Palmer, K. Papadakis, S. Potter, A. Pouta, L. Qi; Nurses’ Health Study, J.C. Randall, N.W. Rayner, S.M. Ring, M.S. Sandhu, A. Scherag, M.A. Sims, K. Song, N. Soranzo, E.K. Speliotes; Diabetes Genetics Initiative, H.E. Syddall, S.A. Teichmann, N.J. Timpson, J.H. Tobias, M. Uda; SardiNIA Study, C.I. Vogel, C. Wallace, D.M. Waterworth, M.N. Weedon; Wellcome Trust Case Control Consortium, C.J. Willer; FUSION, Wraight, X. Yuan, E. Zeggini, J.N. Hirschhorn, D.P. Strachan, W.H. Ouwehand, M.J. Caulfield, N.J. Samani, T.M. Frayling, P. Vollenweider, G. Waeber, V. Mooser, P. Deloukas, M.I. McCarthy, N.J. Wareham, I. Barroso, K.B. Jacobs, S.J. Chanock, R.B. Hayes, C. Lamina, C. Gieger, T. Illig, T. Meitinger, H.E. Wichmann, P. Kraft, S.E. Hankinson, D.J. Hunter, F.B. Hu, H.N. Lyon, B.F. Voight, M. Ridderstrale, L. Groop, P. Scheet, S. Sanna, G.R. Abecasis, G. Albai, R. Nagaraja, D. Schlessinger, A.U. Jackson, J. Tuomilehto, F.S. Collins, M. Boehnke, K.L. Mohlke. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768–775 (2008)
G. Thorleifsson, G.B. Walters, D.F. Gudbjartsson, V. Steinthorsdottir, P. Sulem, A. Helgadottir, U. Styrkarsdottir, S. Gretarsdottir, S. Thorlacius, I. Jonsdottir, T. Jonsdottir, E.J. Olafsdottir, G.H. Olafsdottir, T. Jonsson, F. Jonsson, K. Borch-Johnsen, T. Hansen, G. Andersen, T. Jorgensen, T. Lauritzen, K.K. Aben, A.L. Verbeek, N. Roeleveld, E. Kampman, L.R. Yanek, L.C. Becker, L. Tryggvadottir, T. Rafnar, D.M. Becker, J. Gulcher, L.A. Kiemeney, O. Pedersen, A. Kong, U. Thorsteinsdottir, K. Stefansson, Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. 41, 18–24 (2009)
C.J. Willer, E.K. Speliotes, R.J. Loos, S. Li, C.M. Lindgren, I.M. Heid, S.I. Berndt, A.L. Elliott, A.U. Jackson, C. Lamina, G. Lettre, N. Lim, H.N. Lyon, S.A. McCarroll, K. Papadakis, L. Qi, J.C. Randall, R.M. Roccasecca, S. Sanna, P. Scheet, M.N. Weedon, E. Wheeler, J.H. Zhao, L.C. Jacobs, I. Prokopenko, N. Soranzo, T. Tanaka, N.J. Timpson, P. Almgren, A. Bennett, R.N. Bergman, S.A. Bingham, L.L. Bonnycastle, M. Brown, N.P. Burtt, P. Chines, L. Coin, F.S. Collins, J.M. Connell, C. Cooper, G.D. Smith, E.M. Dennison, P. Deodhar, P. Elliott, M.R. Erdos, K. Estrada, D.M. Evans, L. Gianniny, C. Gieger, C.J. Gillson, C. Guiducci, R. Hackett, D. Hadley, A.S. Hall, A.S. Havulinna, J. Hebebrand, A. Hofman, B. Isomaa, K.B. Jacobs, T. Johnson, P. Jousilahti, Z. Jovanovic, K.T. Khaw, P. Kraft, M. Kuokkanen, J. Kuusisto, J. Laitinen, E.G. Lakatta, J. Luan, R.N. Luben, M. Mangino, W.L. McArdle, T. Meitinger, A. Mulas, P.B. Munroe, N. Narisu, A.R. Ness, K. Northstone, S. O’Rahilly, C. Purmann, M.G. Rees, M. Ridderstråle, S.M. Ring, F. Rivadeneira, A. Ruokonen, M.S. Sandhu, J. Saramies, L.J. Scott, A. Scuteri, K. Silander, M.A. Sims, K. Song, J. Stephens, S. Stevens, H.M. Stringham, Y.C. Tung, T.T. Valle, C.M. Van Duijn, K.S. Vimaleswaran, P. Vollenweider, G. Waeber, C. Wallace, R.M. Watanabe, D.M. Waterworth, N. Watkins; Wellcome Trust Case Control Consortium, J.C. Witteman, E. Zeggini, G. Zhai, M.C. Zillikens, D. Altshuler, M.J. Caulfield, S.J. Chanock, I.S. Farooqi, L. Ferrucci, J.M. Guralnik, A.T. Hattersley, F.B. Hu, M.R. Jarvelin, M. Laakso, V. Mooser, K.K. Ong, W.H. Ouwehand, V. Salomaa, N.J. Samani, T.D. Spector, T. Tuomi, J. Tuomilehto, M. Uda, A.G. Uitterlinden, N.J. Wareham, P. Deloukas, T.M. Frayling, L.C. Groop, R.B. Hayes, D.J. Hunter, K.L. Mohlke, L. Peltonen, D. Schlessinger, D.P. Strachan, H.E. Wichmann, M.I. McCarthy, M. Boehnke, I. Barroso, G.R. Abecasis, J.N. Hirschhorn. Genetic investigation of anthropometric traits consortium, six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25–34 (2009)
M. Benzinou, J.W. Creemers, H. Choquet, S. Lobbens, C. Dina, E. Durand, A. Guerardel, P. Boutin, B. Jouret, B. Heude, B. Balkau, J. Tichet, M. Marre, N. Potoczna, F. Horber, C. Le Stunff, S. Czernichow, A. Sandbaek, T. Lauritzen, K. Borch-Johnsen, G. Andersen, W. Kiess, A. Körner, P. Kovacs, P. Jacobson, L.M. Carlsson, A.J. Walley, T. Jørgensen, T. Hansen, O. Pedersen, D. Meyre, P. Froguel, Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat. Genet. 40, 943–945 (2008)
D. Meyre, J. Delplanque, J.C. Chèvre, C. Lecoeur, S. Lobbens, S. Gallina, E. Durand, V. Vatin, F. Degraeve, C. Proença, S. Gaget, A. Körner, P. Kovacs, W. Kiess, J. Tichet, M. Marre, A.L. Hartikainen, F. Horber, N. Potoczna, S. Hercberg, C. Levy-Marchal, F. Pattou, B. Heude, M. Tauber, M.I. McCarthy, A.I. Blakemore, A. Montpetit, C. Polychronakos, J. Weill, L.J. Coin, J. Asher, P. Elliott, M.R. Järvelin, S. Visvikis-Siest, B. Balkau, R. Sladek, D. Balding, A. Walley, C. Dina, P. Froguel, Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat. Genet. 41, 157–159 (2009)
E.K. Speliotes, C.J. Willer, S.I. Berndt, K.L. Monda, G. Thorleifsson, A.U. Jackson, H. Lango Allen, C.M. Lindgren, J. Luan, R. Mägi, J.C. Randall, S. Vedantam, T.W. Winkler, L. Qi, T. Workalemahu, I.M. Heid, V. Steinthorsdottir, H.M. Stringham, M.N. Weedon, E. Wheeler, A.R. Wood, T. Ferreira, R.J. Weyant, A.V. Segrè, K. Estrada, L. Liang, J. Nemesh, J.H. Park, S. Gustafsson, T.O. Kilpeläinen, J.Yang, N. Bouatia-Naji, T. Esko, M.F. Feitosa, Z. Kutalik, M. Mangino, S. Raychaudhuri, A. Scherag, A.V. Smith, R. Welch, J.H. Zhao, K.K. Aben, D.M. Absher, N. Amin, A.L. Dixon, E. Fisher, N.L. Glazer, M.E. Goddard, N.L. Heard-Costa, V. Hoesel, J.J. Hottenga, A. Johansson, T. Johnson, S. Ketkar, C. Lamina, S. Li, M.F. Moffatt, R.H. Myers, N. Narisu, J.R. Perry, M.J. Peters, M. Preuss, S. Ripatti, F. Rivadeneira, C. Sandholt, L.J. Scott, N.J. Timpson, J.P. Tyrer, S. van Wingerden, R.M. Watanabe, C.C. White, F. Wiklund, C. Barlassina, D.I. Chasman, M.N. Cooper, J.O. Jansson, R.W. Lawrence, N. Pellikka, I. Prokopenko, J. Shi, E. Thiering, H. Alavere, M.T. Alibrandi, P. Almgren, A.M. Arnold, T. Aspelund, L.D. Atwood, B. Balkau, A.J. Balmforth, A.J. Bennett, Y. Ben-Shlomo, R.N. Bergman, S. Bergmann, H. Biebermann, A.I. Blakemore, T. Boes, L.L. Bonnycastle, S.R. Bornstein, M.J. Brown, T.A. Buchanan, F. Busonero, H. Campbell, F.P. Cappuccio, C. Cavalcanti-Proença, Y.D. Chen, C.M. Chen, P.S. Chines, R. Clarke, L. Coin, J. Connell, I.N. Day, M. den Heijer, J. Duan, S. Ebrahim, P. Elliott, R. Elosua, G. Eiriksdottir, M.R. Erdos, J.G. Eriksson, M.F. Facheris, S.B. Felix, P. Fischer-Posovszky, A.R. Folsom, N. Friedrich, N.B. Freimer, M. Fu, S. Gaget, P.V. Gejman, E.J. Geus, C. Gieger, A.P. Gjesing, A. Goel, P. Goyette, H. Grallert, J. Grässler, D.M. Greenawalt, C.J. Groves, V. Gudnason, C. Guiducci, A.L. Hartikainen, N. Hassanali, A.S. Hall, A.S. Havulinna, C. Hayward, A.C. Heath, C. Hengstenberg, A.A. Hicks, A. Hinney, A. Hofman, G. Homuth, J. Hui, W. Igl, C. Iribarren, B. Isomaa, K.B. Jacobs, I. Jarick, E. Jewell, U. John, T. Jørgensen, P. Jousilahti, A. Jula, M. Kaakinen, E. Kajantie, L.M. Kaplan, S. Kathiresan, J. Kettunen, L. Kinnunen, J.W. Knowles, I. Kolcic, I.R. König, S. Koskinen, P. Kovacs, J. Kuusisto, P. Kraft, K. Kvaløy, J. Laitinen, O. Lantieri, C. Lanzani, L.J. Launer, C. Lecoeur, T. Lehtimäki, G. Lettre, J. Liu, M.L. Lokki, M. Lorentzon, R.N. Luben, B. Ludwig; MAGIC, P. Manunta, D. Marek, M. Marre, N.G. Martin, W.L. McArdle, A. McCarthy, B. McKnight, T. Meitinger, O. Melander, D. Meyre, K. Midthjell, G.W. Montgomery, M.A. Morken, A.P. Morris, R. Mulic, J.S. Ngwa, M. Nelis, M.J. Neville, D.R. Nyholt, C.J. O’Donnell, S. O’Rahilly, K.K. Ong, B. Oostra, G. Paré, A.N. Parker, M. Perola, I. Pichler, K.H. Pietiläinen, C.G. Platou, O. Polasek, A. Pouta, S. Rafelt, O. Raitakari, N.W. Rayner, M. Ridderstråle, W. Rief, A. Ruokonen, N.R. Robertson, P. Rzehak, V. Salomaa, A.R. Sanders, M.S. Sandhu, S. Sanna, J. Saramies, M.J. Savolainen, S. Scherag, S. Schipf, S. Schreiber, H. Schunkert, K. Silander, J. Sinisalo, D.S. Siscovick, J.H. Smit, N.Soranzo, U.Sovio, J. Stephens, I. Surakka, A.J. Swift, M.L. Tammesoo, J.C. Tardif, M. Teder-Laving, T.M. Teslovich, J.R. Thompson, B. Thomson, A. Tönjes, T. Tuomi, J.B. van Meurs, G.J. van Ommen, V. Vatin, J. Viikari, S. Visvikis-Siest, V. Vitart, C.I. Vogel, B.F.Voight, L.L. Waite, H. Wallaschofski, G.B. Walters, E. Widen, S. Wiegand, S.H. Wild, G. Willemsen, D.R. Witte, J.C. Witteman, J. Xu, Q. Zhang, L. Zgaga, A. Ziegler, P. Zitting, J.P. Beilby, I.S. Farooqi, J. Hebebrand, H.V. Huikuri, A.L. James, M. Kähönen, D.F. Levinson, F. Macciardi, M.S. Nieminen, C. Ohlsson, L.J. Palmer, P.M. Ridker, M. Stumvoll, J.S. Beckmann, H. Boeing, E. Boerwinkle, D.I. Boomsma, M.J. Caulfield, S.J. Chanock, F.S. Collins, L.A. Cupples, G.D. Smith, J. Erdmann, P.Froguel, H. Grönberg, U. Gyllensten, P. Hall, T. Hansen, T.B. Harris, A.T. Hattersley, R.B. Hayes, J. Heinrich, F.B. Hu, K. Hveem, T. Illig, M.R. Jarvelin, J. Kaprio, F. Karpe, K.T. Khaw, L.A. Kiemeney, H. Krude, M. Laakso, D.A. Lawlor, A. Metspalu, P.B. Munroe, W.H. Ouwehand, O. Pedersen, B.W. Penninx, A. Peters, P.P. Pramstaller, T. Quertermous, T. Reinehr, A. Rissanen, I. Rudan, N.J. Samani, P.E. Schwarz, A.R. Shuldiner, T.D. Spector, J. Tuomilehto, M. Uda, A. Uitterlinden, T.T.Valle, M. Wabitsch, G. Waeber, N.J. Wareham, H. Watkins; Procardis Consortium, J.F. Wilson, A.F. Wright, M.C. Zillikens, N. Chatterjee, S.A. McCarroll, S. Purcell, E.E. Schadt, P.M. Visscher, T.L.Assimes, I.B. Borecki, P. Deloukas, C.S. Fox, L.C. Groop, T. Haritunians, D.J. Hunter, R.C. Kaplan, K.L. Mohlke, J.R. O’Connell, L. Peltonen, D. Schlessinger, D.P. Strachan, C.M. van Duijn, H.E. Wichmann, T.M. Frayling, U. Thorsteinsdottir, G.R. Abecasis, I. Barroso, M. Boehnke, K. Stefansson, K.E. North, M.I. McCarthy, J.N. Hirschhorn, E. Ingelsson, R.J. Loos. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42:937–948(2010)
W. Wen, Y.S. Cho, W. Zheng, R. Dorajoo, N. Kato, L. Qi, C.H. Chen, R.J. Delahanty, Y. Okada, Y. Tabara, D. Gu, D. Zhu, C.A. Haiman, Z. Mo, Y.T. Gao, S.M. Saw, M.J. Go, F. Takeuchi, L.C. Chang, Y. Kokubo, J. Liang, M. Hao, L. Le Marchand, Y. Zhang, Y. Hu, T.Y. Wong, J. Long, B.G. Han, M. Kubo, K. Yamamot o, M.H. Su, T. Miki, B.E. Henderson, H. Song, A.Tan, J. He, D.P. Ng, Q. Cai, T. Tsunoda, F.J. Tsai, N. Iwai, G.K. Chen, J. Shi, J. Xu, X. Sim, Y.B. Xiang, S. Maeda, R.T. Ong, C. Li, Y. Nakamura, T. Aung, N. Kamatani, J.J. Liu, W. Lu, M. Yokota, M. Seielstad, C.S. Fann; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, J.Y. Wu, J.Y. Lee, F.B. Hu, T. Tanaka, E.S. Tai, X.O. Shu. Meta-analysis identifies common variants associated with body mass index in East Asians. Nat. Genet. 44, 307–311 (2012)
Y. Okada, M. Kubo, H. Ohmiya, A. Takahashi, N. Kumasaka, N. Hosono, S. Maeda, W. Wen, R. Dorajoo, M.J. Go, W. Zheng, N. Kato, J.Y. Wu, Q. Lu, GIANT consortium, T. Tsunoda, K. Yamamoto, Y. Nakamura, N. Kamatani, T. Tanaka, Common variants at CDKAL1 and KLF9 are associated with body mass index in East Asian populations. Nat. Genet. 44, 302–306 (2012)
B. Xi, J. Mi, Genome-wide association studies of common obesity: now and future. Biomed. Environ. Sci. 26, 787–791 (2013)
B. Xi, Y. Shen, M. Zhang, X. Liu, X. Zhao, L. Wu, H. Cheng, D. Hou, K. Lindpaintner, L. Liu, J. Mi, X. Wang, The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China. BMC Med. Genet. 11, 107 (2010)
L. Wu, B. Xi, M. Zhang, Y. Shen, X. Zhao, H. Cheng, D. Hou, D. Sun, J. Ott, X. Wang, J. Mi, Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes 59, 3085–3089 (2010)
B. Xi, Y. Shen, K.H. Reilly, X. Zhao, H. Cheng, D. Hou, X. Wang, J. Mi, Sex-dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a Chinese children population. Clin. Endocrinol. (Oxf.) 79, 523–528 (2013)
B. Xi, H. Cheng, Y. Shen, G.R. Chandak, X. Zhao, D. Hou, L. Wu, X. Wang, J. Mi, Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese Children. PLoS One 8, e56472 (2013)
V.T. Samuel, K.F. Petersen, G.I. Shulman, Lipid-induced insulin resistance: unraveling the mechanism. Lancet 375, 2267–2277 (2010)
M.R. Wing, J.M. Ziegler, C.D. Langefeld, B.H. Roh, N.D. Palmer, E.J. Mayer-Davis, M.J. Rewers, S.M. Haffner, L.E. Wagenknecht, D.W. Bowden, Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int. J. Obes. (Lond.) 35, 1173–1182 (2011)
I. Shimaoka, K. Kamide, M. Ohishi, T. Katsuya, H. Akasaka, S. Saitoh, K. Sugimoto, R. Oguro, A. Congrains, T. Fujisawa, K. Shimamoto, T. Ogihara, H. Rakugi, Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hypertens. Res. 33, 214–218 (2010)
R. Do, S.D. Bailey, K. Desbiens, A. Belisle, A. Montpetit, C. Bouchard, L. Pérusse, M.C. Vohl, J.C. Engert, Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 57, 1147–1150 (2008)
M.R. Wing, J. Ziegler, C.D. Langefeld, M.C. Ng, S.M. Haffner, J.M. Norris, M.O. Goodarzi, D.W. Bowden, Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum. Genet. 125, 615–626 (2009)
S. Robiou-du-Pont, A. Bonnefond, L. Yengo, E. Vaillant, S. Lobbens, E. Durand, J. Weill, O. Lantieri, B. Balkau, G. Charpentier, M. Marre, P. Froguel, D. Meyre, Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. Int. J. Obes. (Lond.) 37, 980–985 (2013)
T. Fall, J. Arnlöv, C. Berne, E. Ingelsson, The role of obesity-related genetic loci in insulin sensitivity. Diabet. Med. 29, e62–e66 (2012)
B. Riffo, S. Asenjo, K. Sáez, C. Aguayo, I. Muñoz, P. Bustos, C. Celis-Morales, J. Lagos, J. Sapunar, N. Ulloa, FTO gene is related to obesity in Chilean Amerindian children and impairs HOMA-IR in prepubertal girls. Pediatr. Diabetes 13, 384–391 (2012)
J.A. Jacobsson, J. Klovins, I. Kapa, P. Danielsson, V. Svensson, M. Ridderstråle, U. Gyllensten, C. Marcus, R. Fredriksson, H.B. Schiöth, Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents. Int. J. Obes. (Lond.) 32, 1730–1735 (2008)
X.Y. Shan, B. Xi, H. Cheng, D.Q. Hou, Y. Wang, J. Mi, Prevalence and behavioral risk factors of overweight and obesity among children aged 2–18 in Beijing, China. Int. J. Pediatr. Obes. 5, 383–389 (2010)
T.M. Wallace, J.C. Levy, D.R. Matthews, Use and abuse of HOMA modeling. Diabetes Care 27, 1487–1495 (2004)
E.S. Ford, W.H. Giles, A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 26, 575–581 (2003)
Y. Shen, L. Wu, B. Xi, X. Liu, X. Zhao, H. Cheng, D. Hou, X. Wang, J. Mi, GCKR variants increase triglycerides while protecting from insulin resistance in Chinese children. PLoS One 8, e55350 (2013)
J. Yin, M. Li, L. Xu, Y. Wang, H. Cheng, X. Zhao, J. Mi, Insulin resistance determined by homeostasis model assessment (HOMA) and associations with metabolic syndrome among Chinese children and teenagers. Diabetol. Metab. Syndr. 5, 71 (2013)
X. Zhao, B. Xi, Y. Shen, L. Wu, D. Hou, H. Cheng, J. Mi, An obesity genetic risk score is associated with metabolic syndrome in Chinese children. Gene 535, 299–302 (2014)
B. Xi, X. Zhao, Y. Shen, L. Wu, K. Hotta, D. Hou, H. Cheng, X. Wang, J. Mi, Associations of obesity susceptibility loci with hypertension in Chinese children. Int. J. Obes. (Lond.) 37, 926–930 (2013)
Acknowledgments
This work was supported by National Basic Research Program of China (973 Program, 2013CB530605), Beijing Key Science and Technology Program (D111100000611002), Beijing Health System Leading Talent Grant (2009-1-08), and the Research Fund for the Doctoral Program of Higher Education of China (20120131120004).
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Bo Xi and Xiaoyuan Zhao contributed equally to this work.
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12020_2014_217_MOESM1_ESM.doc
Association of 11 obesity-associated SNPs with HOMA-IR index stratified by pubertal status. Supplementary material 1 (DOC 92 kb)
12020_2014_217_MOESM2_ESM.doc
Association of 11 obesity-associated SNPs with risk of IR stratified by pubertal status. Supplementary material 2 (DOC 89 kb)
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Xi, B., Zhao, X., Shen, Y. et al. An obesity genetic risk score predicts risk of insulin resistance among Chinese children. Endocrine 47, 825–832 (2014). https://doi.org/10.1007/s12020-014-0217-y
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DOI: https://doi.org/10.1007/s12020-014-0217-y