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Cell Tracing Techniques in Stem Cell Transplantation

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Abstract

Pluripotent stem cells have shown great therapeutic promise because of their natural capacity to regenerate damaged tissue. Likewise, autologous stem cells or genetically modified stem cells have already been successfully applied in animal or clinical experimental studies including cardiopathy, diabetic disease, system lupus erythema, pancreatic disease, and liver disease. In these studies regarding stem cell transplants in different diseases, identifying the location of implanted cells and distinguishing them from endogenous cells is the first and most important step. Moreover, different tracing techniques were applied in different studies for their different sensitivity, dynamic range, convenience and reliability of their assays. Therefore, we will here review different tracing techniques and their applications in stem cell transplants, including both experiment studies and preclinical trials.

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Acknowledgements

We would like to thank the members of the Tissue Engineering Lab (Jieshi Hu, Faming Chen, and Yan Jin) for helpful discussions concerning the topics presented in this review. The work about stem cell research was supported by Chinese National Foundation of National Sciences (30470788) and Natural Science Foundation of Shanxi Province (2006K09-G8).

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Authors and Affiliations

  1. Department of Gastroenterology, Xijing Hospital, Fourth Military Medical University, 17 Changle Western Road, Xi’an, Shaanxi Province, 710032, China

    Li Yan, Ying Han, Yuanlong He, Huahong Xie, Jingmei Liu, Lina Zhao, Jingbo Wang, Liuchun Gao & Daiming Fan

  2. Department of Gastroenterology, 401 Hospital of PLA, Qingdao, Shandong province, 266071, China

    Li Yan

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  1. Li Yan
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  2. Ying Han
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  3. Yuanlong He
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Correspondence to Daiming Fan.

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Li Yan, Ying Han and Yuanlong He contributed equally to this work.

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Yan, L., Han, Y., He, Y. et al. Cell Tracing Techniques in Stem Cell Transplantation. Stem Cell Rev 3, 265–269 (2007). https://doi.org/10.1007/s12015-007-9004-y

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  • DOI: https://doi.org/10.1007/s12015-007-9004-y

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