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Multicenter Study on Adult Growth Hormone Level in Postoperative Pituitary Tumor Patients

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Abstract

The objective of this study is to observe the adult growth hormone level in postoperative pituitary tumor patients of multi-centers, and explore the change of hypophyseal hormones in postoperative pituitary tumor patients. Sixty patients with pituitary tumor admitted during March, 2011–March, 2012 were selected. Postoperative hypophyseal hormone deficiency and the change of preoperative, intraoperative, and postoperative growth hormone levels were recorded. Growth hormone hypofunction was the most common hormonal hypofunction, which took up to 85.0 %. Adrenocortical hormone hypofunction was next to it and accounted for 58.33 %. GH + ACTH + TSH + Gn deficiency was the most common in postoperative hormone deficiency, which took up to 40.00 %, and GH + ACTH + TSH + Gn + AVP and GH deficiencies were next to it and accounted for 23.33 and 16.67 %, respectively. The hormone levels in patients after total pituitary tumor resection were significantly lower than those after partial pituitary tumor resection, and the difference was statistically significant; growth hormone and serum prolactin levels after surgery in two groups were decreased, and the difference was statistically significant. The incidence rate of growth hormone deficiency in postoperative pituitary tumor patients is high, which is usually complicated with deficiency of various hypophyseal hormones. In clinical, we should pay attention to the levels of the hypopnyseal hormones, and take timely measures to avoid postoperative complications.

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Authors and Affiliations

  1. Department of Neurosurgery, Chengdu Military General Hospital, 270 Rong Du Road, Chengdu, 610083, Sichuan Province, China

    Jing-min Cheng, Jian-wen Gu, Yong-qin Kuang, Yuan Ma, Xun Xia, Tao Yang, Min Lu, Wei-qi He, Zhi-yong Sun & Yan-chao Zhang

  2. Graduate Management Team, Third Military Medical University, chongqing, 400038, China

    Jing-min Cheng, Yuan Ma, Xun Xia, Tao Yang, Min Lu, Zhi-yong Sun & Yan-chao Zhang

  3. Air Force General Hospital of PLA, No. 30 Fucheng Road, Haidian District, Beijing, China

    Jian-wen Gu

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  1. Jing-min Cheng
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  4. Yuan Ma
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Correspondence to Jian-wen Gu.

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Cheng, Jm., Gu, Jw., Kuang, Yq. et al. Multicenter Study on Adult Growth Hormone Level in Postoperative Pituitary Tumor Patients. Cell Biochem Biophys 71, 1239–1242 (2015). https://doi.org/10.1007/s12013-014-0334-5

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  • DOI: https://doi.org/10.1007/s12013-014-0334-5

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