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Effect of Binghuang Ear Drop Treatment on Otitis Externa in Guinea Pigs

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Abstract

To investigate the pharmacodynamic effects of Binghuang ear drop on acute suppurative otitis externa in guinea pig model. Thirty guinea pigs were randomly divided into three groups, with ten animals in each group. Group A animals had normal ear canal and Binghuang ear drops (two drops, B.I.D) were applied in both ears for 7 days; Group B animals had induced otitis externa and received identical prescription as group A; Group C had normal ear canal and were treated with normal saline (two drops, B.I.D) for 7 days. After the treatments, the external morphology of ear canals was observed and the paraffin sections of external auditory canal were prepared and examined under the microscope. The inflammatory manifestation and cell infiltration into the skin of group B was significantly attenuated after the Binghuang ear drops treatment. In contrast, no allergy or side effects were produced by Binghuang ear drops application in the animals with normal ear canals. Binghuang ear drops could be used to treat acute otitis externa by eliciting anti-bacterial effects.

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Acknowledgments

This project was funded by the Transformation Fund of Scientific and Technological Achievement, the General Hospital of Chinese PLA.

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Authors declare no conflict of interest.

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Authors and Affiliations

  1. Institute of Otorhinolaryngology, Chinese PLA General Hospital, Beijing, 100853, China

    Suo-qiang Zhai, Ning Yu, Wei-Wei Guo & Yue Zhang

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  1. Suo-qiang Zhai
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  2. Ning Yu
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  3. Wei-Wei Guo
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  4. Yue Zhang
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Correspondence to Suo-qiang Zhai.

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Zhai, Sq., Yu, N., Guo, WW. et al. Effect of Binghuang Ear Drop Treatment on Otitis Externa in Guinea Pigs. Cell Biochem Biophys 70, 1813–1815 (2014). https://doi.org/10.1007/s12013-014-0134-y

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  • DOI: https://doi.org/10.1007/s12013-014-0134-y

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