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The Structure, Function, and Regulation of Mycobacterium FtsZ

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Abstract

FtsZ is a widely distributed major cytoskeletal protein involved in the archaea and bacteria cell division. It is the most critical component in the division machinery and similar to tubulin in structure and function. Four major roles of FtsZ have been characterized: cell elongation, GTPase, cell division, and bacterial cytoskeleton. FtsZ subunits can be assembled into protofilaments. Mycobacteria consist of a large family of medical and environmental important bacteria, such as M. leprae, M. tuberculosis, the pathogen of leprosy, and tuberculosis. Structure, function, and regulation of mycobacteria FtsZ are summarized here, together with the implication of FtsZ as potential novel drug target for anti-tuberculosis therapeutics.

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Abbreviations

FtsZ:

Filamentous temperature-sensitive mutant Z

ZipA:

Inner membrane protein A binds directly to Z-ring

FtsA:

Filamentous temperature-sensitive mutant A

ZapA:

Z-ring-associated protein

SepF:

Septum development protein

SulA:

Induction of the cell division inhibitor A

EzrA:

Negative regulator of FtsZ ring formation protein A

MinCD:

Minicell locus protein C and D

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Acknowledgments

This work was supported by the National megaproject for key infectious disease (Grant No. 2008ZX10003-006, 2012ZX10003-003), the Fundamental Research Funds for the Central Universities (Grant No. XDJK2009A003), the National natural science foundation (Grant No. 81071316), the New Century Excellent Talents Programs in Universities (NCET-11-0703), and the Excellent PhD thesis fellowship of southwest university (Grant Nos. kb2009010 and ky2011003).

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  1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, 400715, China

    Weiling Hong, Wanyan Deng & Jianping Xie

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  1. Weiling Hong
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Correspondence to Jianping Xie.

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Hong, W., Deng, W. & Xie, J. The Structure, Function, and Regulation of Mycobacterium FtsZ. Cell Biochem Biophys 65, 97–105 (2013). https://doi.org/10.1007/s12013-012-9415-5

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