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Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

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Abstract

This study aims to investigate the effects of a tripeptide iron (REE-Fe) on iron-deficiency anemia rats. Sprague-Dawley rats were randomly divided into seven groups: a normal control group, an iron-deficiency control group, and iron-deficiency groups treated with ferrous sulfate (FeSO4), ferrous glycinate (Fe-Gly), or REE-Fe at low-, medium-, or high-dose groups. The rats in the iron-deficiency groups were fed on an iron-deficient diet to establish iron-deficiency anemia (IDA) model. After the model established, different iron supplements were given to the rats once a day by intragastric administration for 21 days. The results showed that REE-Fe had effective restorative action returning body weight, organ coefficients, and hematological parameters in IDA rats to normal level. In addition, comparing with FeSO4 or Fe-Gly, high-dose REE-Fe was more effective on improving the levels of renal coefficient, total iron-binding capacity, and transferrin. Furthermore, the liver hepcidin messenger RNA (mRNA) expression in the high-dose group was significantly higher (p < 0.05) than that in the FeSO4 or Fe-Gly group and showed no significant difference (p > 0.05) with the normal control group. The findings suggest that REE-Fe is an effective source of iron supplement for IDA rats and might be exploited as a new iron fortifier.

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Authors and Affiliations

  1. Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People’s Republic of China

    Chen Xiao, Qingyu Wang, Zhongyao Du, Lu Jiang, Silu Chen, Hao Zhang & Fazheng Ren

  2. Department of Animal Science, Cornell University, Ithaca, NY, 14853, USA

    Xingen Lei

  3. Beijing Higher Institution Engineering Research Center of Animal Product, Beijing, 100083, People’s Republic of China

    Mingjie Zhang

Authors
  1. Chen Xiao
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  2. Xingen Lei
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  3. Qingyu Wang
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  4. Zhongyao Du
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  5. Lu Jiang
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  6. Silu Chen
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  7. Mingjie Zhang
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  8. Hao Zhang
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  9. Fazheng Ren
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Correspondence to Hao Zhang.

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Xiao, C., Lei, X., Wang, Q. et al. Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats. Biol Trace Elem Res 169, 211–217 (2016). https://doi.org/10.1007/s12011-015-0412-6

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  • DOI: https://doi.org/10.1007/s12011-015-0412-6

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