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Dietary Iodine and Selenium Affected the mRNA Expression Levels of Skin Monodeiodinase (II, III) in Liaoning Cashmere Goats

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Abstract

Livestock are frequently provided nutrient-depleted diets, which can negatively impact animal health and productivity. In our previous trial, we found that iodine (I) supplementation (not selenium (Se)) could increase cashmere production. In order to explore the role of I and Se in cashmere growth, we investigated the effects of dietary I and Se supplementation in Liaoning cashmere goats. Serum thyroid hormone status and the mRNA expression levels of skin monodeiodinase (MDII, MDIII) were measured during the cashmere fiber growth period. Forty-eight 2.5-year-old Liaoning cashmere goats (38.6 ± 2.65 kg BW) were divided into six equal groups, and their diets were supplemented with I (0, 2, or 4 mg/kg DM) and Se (0 or 1 mg/kg DM) in a 2 × 3 factorial treatment design. The six treatment groups were: I0Se0, I2Se0, I4Se0, I0Se1, I2Se1, and I4Se1. Concentrations of I and Se in the basal diet (group I0Se0) were 0.67 and 0.09 mg/kg DM, respectively. The trial started in September of 2009 and lasted 70 days. For every measured parameter, supplemental Se had no significant effect on thyroid hormones, but improved the mRNA expression levels of skin MDIII (P < 0.01). However, supplemental I increased levels of thyroid hormones (thyroxine and triiodothyronine) and improved the mRNA expression levels of skin MDII (P < 0.05). These results show that the addition of I to cashmere goat feedstock may be an effective means of increasing cashmere production through thyroid hormones regulating the mRNA expression of skin MDII.

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Acknowledgments

This work was supported by the Independent Innovation Fund of Jiangsu province (no. 0260511209) and by an earmarked fund for the Modern Agro-industry Technology Research System.

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Authors and Affiliations

  1. Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, People’s Republic of China

    Feng Qin & Jie Yang

  2. State Key Laboratory for Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People’s Republic of China

    Jianyun Li, Xiaoping Zhu & Zhihai Jia

  3. Shandong Institute of Agricultural Management, Jinan, 250100, People’s Republic of China

    Jiaping Zhou

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  1. Feng Qin
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  2. Jianyun Li
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  3. Xiaoping Zhu
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Correspondence to Xiaoping Zhu.

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Qin, F., Li, J., Zhu, X. et al. Dietary Iodine and Selenium Affected the mRNA Expression Levels of Skin Monodeiodinase (II, III) in Liaoning Cashmere Goats. Biol Trace Elem Res 151, 360–364 (2013). https://doi.org/10.1007/s12011-012-9583-6

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  • DOI: https://doi.org/10.1007/s12011-012-9583-6

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