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Protective Effect of Zingiber officinale Against Dalton’s Lymphoma Ascites Tumour by Regulating Inflammatory Mediator and Cytokines

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Abstract

The aim of the present investigation was to evaluate Zingiber officinale paste against Dalton’s lymphoma ascites (DLA)-induced tumours in Swiss albino mice. Experimental animals received Z. officinale paste (low dose 100 mg/kg bw and high dose 500 mg/kg bw) orally for eight alternative days. Treatment with Z. officinale paste showed significant increase in haemoglobin level and decrease in aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (γ-GT) level. Z. officinale paste reduced the inflammatory mediators and cytokine levels, such as inducible nitric oxide (iNOS), tumour necrosis factor level (TNF-α) and interleukin-1β (IL-1β). Treatment with Z. officinale paste also significantly increased the antioxidant enzyme level, such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione transferase (GST), and decreased the lipid peroxidation. Treatment also increased the vitamin C and E levels in treated animals compared with the DLA-bearing host. Histopathological studies also confirmed the protective influence of Z. officinale paste against DLA. The present study suggested that Z. officinale paste could be used as natural spice and a potent antitumour agent.

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Acknowledgments

The authors are grateful to Dr. C. Guruvayoorappan, Assistant Professor, Division of Cancer Research, Regional Cancer Center, Thiruvananthapuram, for his help and guidance during the course of this study.

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Authors and Affiliations

  1. Department of Food Processing and Engineering, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, 641114, India

    Sundararaj Rubila & Thottiam Vasudevan Ranganathan

  2. Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, 641114, India

    Kunnathur Murugesan Sakthivel

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  1. Sundararaj Rubila
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Correspondence to Thottiam Vasudevan Ranganathan.

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Rubila, S., Ranganathan, T.V. & Sakthivel, K.M. Protective Effect of Zingiber officinale Against Dalton’s Lymphoma Ascites Tumour by Regulating Inflammatory Mediator and Cytokines. Appl Biochem Biotechnol 180, 1482–1496 (2016). https://doi.org/10.1007/s12010-016-2181-x

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