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Radical Prostatectomy as Primary Treatment of High-risk Prostate Cancer

  • Prostate Cancer (R Reiter, Section Editor)
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Abstract

High-risk prostate cancer (PCa), established according to the d’Amico criteria or other prognostic tools, remains very heterogeneous, including a third of patients with excellent prognosis in whom surgical treatment can result in long-term progression-free survival. In contrast, a substantial proportion of high risk will not be cured by local treatment alone and might benefit from a more aggressive multimodal adjuvant treatment strategy. However, to date, except in one adjuvant radiotherapy series, no neoadjuvant or adjuvant therapy has shown a survival improvement after radical prostatectomy for high-risk PCa. Recent observational studies tend to prove that radical prostatectomy may offer benefits over radiotherapy in disease-free and overall survival. However, good Level 1 evidence is lacking and further prospective studies are warranted to directly compare the outcomes of radical prostatectomy to combined radiation and hormonal therapy in high-risk patients.

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  1. Department of Urology, APHP, CHU Henri Mondor, 51 Avenue de Lattre de Tassigny, 94010, Créteil, France

    Alexandre Ingels, Alexandre de la Taille & Guillaume Ploussard

  2. INSERM U955, Equipe 7, Université Paris 12, Créteil, France

    Guillaume Ploussard

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  1. Alexandre Ingels
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Correspondence to Guillaume Ploussard.

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Ingels, A., de la Taille, A. & Ploussard, G. Radical Prostatectomy as Primary Treatment of High-risk Prostate Cancer. Curr Urol Rep 13, 179–186 (2012). https://doi.org/10.1007/s11934-012-0240-6

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