Diagnostic Thresholds in Osteoporosis: How Are They Used in Clinical Trials?
- Ronald C. HamdyAffiliated withJames H. Quillen College of Medicine, East Tennessee State University Email author
- , Dustin M. PriceAffiliated withJames H. Quillen College of Medicine
- , Miriam M. MottlAffiliated withUniversity of Rostock Medical School
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Clinical trials are used to determine the efficacy and safety of a medication prior to approval for commercial use and to influence the prescribing habits of clinicians. The lack of uniformity in the diagnostic thresholds used in clinical trials on osteoporosis makes it difficult to compare the results of these trials. The use of placebo, different anatomical sites, T-score cutoff points, and risk factors precludes any meaningful comparison being made between the outcomes of clinical trials. Finally, the lack of uniform reporting format makes it difficult to retrieve important information to compare one medication to another. Because the diagnostic thresholds used affect the outcomes of these trials, health care providers need to be aware of these criteria to determine whether the results of a particular clinical trial can be applied to a particular patient.
KeywordsOsteoporosis Randomized clinical trials Diagnostic thresholds Problems Evidence-based HIP VERT FIT BONE MORE PROOF
- Diagnostic Thresholds in Osteoporosis: How Are They Used in Clinical Trials?
Current Osteoporosis Reports
Volume 9, Issue 3 , pp 160-166
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Randomized clinical trials
- Diagnostic thresholds
- Industry Sectors
- Author Affiliations
- 1. James H. Quillen College of Medicine, East Tennessee State University, P.O. Box 70429, Johnson City, TN, 37614, USA
- 2. James H. Quillen College of Medicine, 1113 High Street Unit 201, Johnson City, TN, 37604, USA
- 3. University of Rostock Medical School, Rostock, Germany