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Disruption of Resting Functional Connectivity in Alzheimer’s Patients and At-Risk Subjects

  • Neuroimaging (DJ Brooks, Section Editor)
  • Published:
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Abstract

The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. In this study, we review the current findings in default mode network and other resting state network studies in AD and MCI patients and at-risk subjects as assessed by resting state functional magnetic resonance imaging.

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Acknowledgment

This work was supported by the project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund and by the Czech Science Foundation grant no. 14-33143S.

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Conflict of Interest

Lenka Krajcovicova and Radek Marecek have received the following grant: project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund.

Michal Mikl has received the following grant: project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund. Dr. Mikl has also received a research grant of Czech Science Foundation no. 14-33143S (Influence of physiological processes on reliability and temporal fluctuations of human brain connectivity measured by fMRI).

Irena Rektorova has received the following grant: project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund. Dr. Rektorova has also received a research grant of Czech Science Foundation no. 14-33143S (Influence of physiological processes on reliability and temporal fluctuations of human brain connectivity measured by fMRI). 

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Authors and Affiliations

  1. Applied Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic

    Lenka Krajcovicova & Irena Rektorova

  2. Multimodal and Functional Imaging Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic

    Radek Marecek & Michal Mikl

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  1. Lenka Krajcovicova
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Correspondence to Irena Rektorova.

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Krajcovicova, L., Marecek, R., Mikl, M. et al. Disruption of Resting Functional Connectivity in Alzheimer’s Patients and At-Risk Subjects. Curr Neurol Neurosci Rep 14, 491 (2014). https://doi.org/10.1007/s11910-014-0491-3

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