Skip to main content

Advertisement

Log in

Low-carbohydrate diets: An update on current research

  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

Abstract

The diabetes and obesity epidemics have stimulated research to assess the benefits and potential risks of low-carbohydrate diets. Carbohydrate comprises less than 45% of calories in carbohydrate-restricted diets, but very low carbohydrate ketogenic diets may restrict carbohydrate to 20 g initially with variability in the carbohydrate level subsequently. Some research suggests that low-carbohydrate diets may achieve better early weight loss than comparison diets higher in carbohydrate. Studies of up to 1 year suggest that weight loss on low-carbohydrate diet is comparable with fat-restricted diets with higher carbohydrate content. Limited research has been conducted to evaluate low-carbohydrate diets in managing type 2 diabetes. Although science continues to advance in this field, current research suggests that low-carbohydrate diets can be a viable option for achieving weight loss and may have beneficial effects on glycemic control, triglyceride levels, and high-density lipoprotein cholesterol levels in some patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. Samaha FF, Iqbal N, Seshadri P, et al.: A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med 2003, 348:2074–2081.

    Article  PubMed  CAS  Google Scholar 

  2. Kirk JK, Graves DE, Craven TE, et al.: Restricted-carbohydrate diets in patients with type 2 diabetes: a meta-analysis. J Am Diet Assoc 2008, 108:91–100.

    Article  PubMed  CAS  Google Scholar 

  3. Yancy WS, Vernon MC, Westman EC: A pilot trial of a low-carbohydrate, ketogenic diet in patients with type 2 diabetes. Metab Syndr Relat Disord 2003, 1:239–243.

    Article  PubMed  CAS  Google Scholar 

  4. Last AR, Wilson SA: Low-carbohydrate diets. Am Fam Physician 2006, 73:1942–1948.

    PubMed  Google Scholar 

  5. Bowman SA, Spence JT: A comparison of low-carbohydrate vs. high-carbohydrate diets: energy restriction, nutrient quality and correlation to body mass index. J Am Coll Nutr 2002, 21:268–274.

    PubMed  Google Scholar 

  6. Cordain L: Implications of plio-pleistocene hominin diets for modern humans. In Early Hominin Diets: The Known, the Unknown, and the Unknowable. Edited by Ungar PS. Oxford, UK: Oxford University Press; 2007:363–383.

    Google Scholar 

  7. Wylie-Rosett J, Vinicor F: Diabetes mellitus. In Present Knowledge in Nutrition, edn 9. Edited by BA Bowman RR. Bowman Washington, DC: International Life Sciences Institute Press; 2006:669–688.

    Google Scholar 

  8. Taubes G: Good Calories, Bad Calories. New York: Knopf Publishing; 2007.

    Google Scholar 

  9. Wylie Rosett J: Nutrition approaches to diabetes mellitus. In Issues and Choices in Clinical Nutrition Practice. Edited by Bloch AS, O’sullivan-Maillet J, Howell WH, Winkler MF. Philadelphia: Lippincott Williams & Wilkins; 2006:337–357.

    Google Scholar 

  10. Kekwick A, Pawan GL, Chalmers TM: Resistance to ketosis in obese subjects. Lancet 1959, 2:1157–159.

    Article  PubMed  CAS  Google Scholar 

  11. Kekwick A, Pawan GL: Metabolic study in human obesity with isocaloric diets high in fat, protein or carbohydrate. Metabolism 1957, 6:447–460.

    PubMed  CAS  Google Scholar 

  12. Stillman I: Doctor’s Quick Weight Loss Diet. Upper Saddle River, NJ: Prentice Hall Publishing; 1967.

    Google Scholar 

  13. Atkins RC: Dr. Atkin’s Diet Revolution. New York: Bantam Books; 1972.

    Google Scholar 

  14. About.Com: Low Carb Diets: Popular Low Carb Diet Plans. http://lowcarbdiets.about.com/od/populardietplans/Popular_Low_Carb_Diet_Plans.htm. Accessed April 28, 2009.

  15. Bernstein R: Dr. Bernstein’s Diabetes Solution: A Complete Guide to Achieving Normal Blood Sugars. New York: Little Brown & Company; 1997.

    Google Scholar 

  16. Audette R, Gilchrist, T: Neanderthin: Eat Like a Caveman to Achieve a Lean, Strong, Healthy Body. New York: St. Martin Press; 1999.

    Google Scholar 

  17. Eades M, Eades, MD: Protein Power. New York: Bantam Books; 1999.

    Google Scholar 

  18. Gutterson C: The Sonoma Diet. New York: HarperCollins Publishers; 2006.

    Google Scholar 

  19. Agatston A: South Beach Diet: The Delicious, Doctor-Designed, Foolproof Plan for Fast and Healthy Weight Loss. Emaus, PA: Roadale Press; 2003.

    Google Scholar 

  20. Steward H, Morrison B, Bakart L: Sugar Busters! Cut Sugar to Trim Fat. New York: Ballantine Books; 1998.

    Google Scholar 

  21. Sears B, Lawren B: Zone: A Dietary Roadmap. New York: HarperCollins Publishers; 1995.

    Google Scholar 

  22. Westman EC, Yancy WS Jr, Mavropoulos JC, et al.: The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr Metab (Lond) 2008, 5:36.

    Article  Google Scholar 

  23. Davis NJ, Tomuta N, Schechter C, et al.: Comparative study of a one year dietary intervention of a low-carbohydrate to a low-fat diet on weight and glycemic control in type 2 diabetes. Diabetes Care 2009, 32:1147–1152.

    Article  PubMed  CAS  Google Scholar 

  24. Vernon MC: Atkins Diabetes Revolution: The Groundbreaking Approach Preventing and Controlling Type 2 Diabetes. New York: HarperCollins; 2004.

    Google Scholar 

  25. Gallop R: The GI diet. New York: Workman Publishing Company; 2003.

    Google Scholar 

  26. American Diabetes Association Scientific Statement. Standards of medical care in diabetes—2009 [no authors listed]. Diabetes Care 2009, 32(Suppl 1):S13–S61.

  27. Dansinger ML, Gleason JA, Griffith JL, et al.: Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 2005, 293:43–53.

    Article  PubMed  CAS  Google Scholar 

  28. Gardner CD, Kiazand A, Alhassan S, et al.: Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA 2007, 297:969–977.

    Article  PubMed  CAS  Google Scholar 

  29. Bravata DM, Sanders L, Huang J, et al.: Efficacy and safety of low-carbohydrate diets: a systematic review. JAMA 2003, 289:1837–1850.

    Article  PubMed  CAS  Google Scholar 

  30. Foster GD, Wyatt HR, Hill JO, et al.: A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 2003, 348:2082–2090.

    Article  PubMed  CAS  Google Scholar 

  31. Astrup A, Meinert Larsen T, Harper A: Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss? Lancet 2004, 364:897–899.

    Article  PubMed  Google Scholar 

  32. Gumbiner B, Wendel JA, McDermott MP: Effects of diet composition and ketosis on glycemia during very-low-energy-diet therapy in obese patients with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1996, 63:110–115.

    PubMed  CAS  Google Scholar 

  33. Nordmann AJ, Nordmann A, Briel M, et al.: Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med 2006, 166:285–293.

    Article  PubMed  CAS  Google Scholar 

  34. Stern L, Iqbal N, Seshadri P, et al.: The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med 2004, 140:778–785.

    PubMed  Google Scholar 

  35. Bergenstal RM, Johnson M, Powers MA, et al.: Adjust to target in type 2 diabetes: comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine. Diabetes Care 2008, 31:1305–1310.

    Article  PubMed  CAS  Google Scholar 

  36. Davis NJ, Wylie-Rosett J: Death to carbohydrate counting? Diabetes Care 2008, 31:1467–1468.

    Article  PubMed  Google Scholar 

  37. Wylie-Rosett J, Albright AA, Apovian C, et al.: 2006–2007 American Diabetes Association Nutrition Recommendations: issues for practice translation. J Am Diet Assoc 2007, 107:1296–1304.

    Article  PubMed  Google Scholar 

  38. Bantle JP, Wylie-Rosett J, Albright AL, et al.: Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 2008, 31(Suppl 1):S61–S78.

    PubMed  CAS  Google Scholar 

  39. Wheeler ML, Pi-Sunyer FX: Carbohydrate issues: type and amount. J Am Diet Assoc 2008, 108:S34–S39.

    Article  PubMed  CAS  Google Scholar 

  40. Stevens A, Robinson DP, Turpin J, et al.: Sudden cardiac death of an adolescent during dieting. South Med J 2002, 95:1047–1049.

    PubMed  Google Scholar 

  41. Yancy WS Jr, Olsen MK, Dudley T, Westman EC: Acid-base analysis of individuals following two weight loss diets. Eur J Clin Nutr 2007, 61:1416–1422.

    Article  PubMed  CAS  Google Scholar 

  42. Davis NJ, Cohen HW, Wylie-Rosett J, Stein D: Serum potassium changes with initiating low-carbohydrate compared to a low-fat weight loss diet in type 2 diabetes. South Med J 2008, 101:46–49.

    PubMed  Google Scholar 

  43. O’Neil DF, Westman EC, Bernstein RK: The effects of a low-carbohydrate regimen on glycemic control and serum lipids in diabetes mellitus. Metab Syndr Relat Disord 2003, 1:291–298.

    Article  Google Scholar 

  44. Burge MR, Castillo KR, Schade DS: Meal composition is a determinant of lispro-induced hypoglycemia in IDDM. Diabetes Care 1997, 20:152–155.

    Article  PubMed  CAS  Google Scholar 

  45. Dietary Reference Intake for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academies Press; 2004.

  46. Wylie-Rosett J, Segal-Isaacson CJ, Segal-Isaacson A: Carbohydrates and increases in obesity: does the type of carbohydrate make a difference? Obes Res 2004, 12(Suppl 2):124S–129S.

    Article  PubMed  CAS  Google Scholar 

  47. Thomas D, Elliott EJ: Low glycaemic index, or low glycaemic load, diets for diabetes mellitus. Cochrane Database Syst Rev 2009:CD006296.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Judith Wylie-Rosett.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wylie-Rosett, J., Davis, N.J. Low-carbohydrate diets: An update on current research. Curr Diab Rep 9, 396–404 (2009). https://doi.org/10.1007/s11892-009-0061-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11892-009-0061-2

Keywords

Navigation