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Advances in the Genetics and Genomics of Heart Failure

  • Heart Failure (HJ Eisen, Section Editor)
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Abstract

Purpose of Review

The purpose of this review is to provide an update on the recent advances in the genetics and genomics of dilated cardiomyopathy and heart failure.

Recent Findings

Over the last decade, the approach to the discovery of the genetic contribution to heart failure has evolved from investigation of rare variants implicated in Mendelian cardiomyopathies through linkage studies and candidate gene studies to the exploration of the contribution of common variants through large-scale genome-wide association and genome-first studies.

Summary

The combination and integration of multiple of case-control heart failure cohorts, refinement of the heart failure phenotype, and utilization of large biobanks linked to electronic health records have advanced the understanding of the heritability of heart failure.

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Acknowledgments

Nosheen Reza reports grants from the National Institutes of Health. She is supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under award number KL2TR001879. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Anjali Tiku Owens reports grant support from the Winkelman Family Fund.

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  1. Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 11 South Tower, Room 11-145 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA

    Nosheen Reza & Anjali Tiku Owens

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Correspondence to Nosheen Reza.

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Anjali Tiku Owens reports personal fees from MyoKardia and Cytokinetics.

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Reza, N., Owens, A.T. Advances in the Genetics and Genomics of Heart Failure. Curr Cardiol Rep 22, 132 (2020). https://doi.org/10.1007/s11886-020-01385-z

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