Abstract
Identifying atrial fibrillation (AF) as the cause of stroke is important because it may trigger a change from therapy with antiplatelet agents to proven superior therapy with anticoagulants. Ischemic stroke due to chronic AF is readily diagnosed, but if patients with intermittent AF remain in sinus rhythm throughout their hospitalization, they will likely be discharged on inferior treatment. Numerous monitoring techniques can identify intermittent AF, and the available evidence suggests that prolonging the duration of monitoring increases the likelihood of detecting AF, which supports the use of monitoring beyond the currently recommended 24 h. Further research is required to definitively establish the utility of cardiac monitoring and identify the optimum method and duration. The promise of new drugs to replace warfarin in the near future reinforces the importance of this line of research. Even using current therapeutics, optimizing the diagnosis of AF remains a key component of quality care for patients with ischemic stroke.
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Fang J, Alderman MH, Keenan NL, et al. Declining US stroke hospitalization since 1997: National Hospital Discharge Survey, 1988–2004. Neuroepidemiology. 2007;29:243–9.
Heinsius T, Bogousslavsky J, Van Melle G. Large infarcts in the middle cerebral artery territory. Etiology and outcome patterns. Neurology. 1998;50:341–50.
Connolly S, Pogue J, Hart R, et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet. 2006;367:1903–12.
Saxena R, Koudstaal PJ Anticoagulants for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or transient ischaemic attack. Cochrane Database Syst Rev 2004:CD000185
Jorgensen HS, Nakayama H, Reith J, et al. Stroke recurrence: predictors, severity, and prognosis. The Copenhagen Stroke Study. Neurology. 1997;48:891–5.
Sandercock P, Bamford J, Dennis M, et al. Atrial fibrillation and stroke: prevalence in different types of stroke and influence on early and long term prognosis (Oxfordshire community stroke project). BMJ. 1992;305:1460–5.
• Connolly SJ, Ezekowitz MD, Yusuf S et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009; 361:1139–51. This study demonstrates the potential of new therapies that may supplant warfarin as the therapy of choice for preventing thromboembolism from atrial fibrillation.
Barsky AJ. Palpitations, arrhythmias, and awareness of cardiac activity. Ann Intern Med. 2001;134:832–7.
Meschia JF, Merrill P, Soliman EZ, et al. Racial disparities in awareness and treatment of atrial fibrillation: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Stroke. 41:581–587.
Cooke G, Doust J, Sanders S. Is pulse palpation helpful in detecting atrial fibrillation? A systematic review. J Fam Pract. 2006;55:130–4.
Fuster V, Ryden LE, Cannom DS, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114:e257–354.
Francis DA, Heron JR, Clarke M. Ambulatory electrocardiographic monitoring in patients with transient focal cerebral ischaemia. J Neurol Neurosurg Psychiatry. 1984;47:256–9.
Rem JA, Hachinski VC, Boughner DR, et al. Value of cardiac monitoring and echocardiography in TIA and stroke patients. Stroke. 1985;16:950–6.
Douen A, Pageau N, Medic S. Usefulness of cardiovascular investigations in stroke management: clinical relevance and economic implications. Stroke. 2007;38:1956–8.
Sposato LA, Klein FR, Jauregui A, et al. Newly diagnosed atrial fibrillation after acute ischemic stroke and transient ischemic attack: importance of immediate and prolonged continuous cardiac monitoring. J Stroke Cerebrovasc Dis. 2010. doi:10.1016/j.jstrokecerebrovasdis.2010.06.010.
Douen AG, Pageau N, Medic S. Serial electrocardiographic assessments significantly improve detection of atrial fibrillation 2.6-fold in patients with acute stroke. Stroke. 2008;39:480–2.
Gaillard N, Deltour S, Vilotijevic B, et al. Detection of paroxysmal atrial fibrillation with transtelephonic EKG in TIA or stroke patients. Neurology. 2010;74:1666–70.
Lazzaro MA, Krishnan K, Prabhakaran S. Detection of atrial fibrillation with concurrent holter monitoring and continuous cardiac telemetry following ischemic stroke and transient ischemic attack. J Stroke Cerebrovasc Dis. 2010. doi:10.1016/j.jstrokecerebrovasdis.2010.05.006.
Koudstaal PJ, van Gijn J, Klootwijk AP, et al. Holter monitoring in patients with transient and focal ischemic attacks of the brain. Stroke. 1986;17:192–5.
Hornig CR, Haberbosch W, Lammers C, et al. Specific cardiological evaluation after focal cerebral ischemia. Acta Neurol Scand. 1996;93:297–302.
Schuchert A, Behrens G, Meinertz T. Impact of long-term ECG recording on the detection of paroxysmal atrial fibrillation in patients after an acute ischemic stroke. Pacing Clin Electrophysiol. 1999;22:1082–4.
Barthelemy JC, Feasson-Gerard S, Garnier P, et al. Automatic cardiac event recorders reveal paroxysmal atrial fibrillation after unexplained strokes or transient ischemic attacks. Ann Noninvasive Electrocardiol. 2003;8:194–9.
Jabaudon D, Sztajzel J, Sievert K, et al. Usefulness of ambulatory 7-day ECG monitoring for the detection of atrial fibrillation and flutter after acute stroke and transient ischemic attack. Stroke. 2004;35:1647–51.
Schaer BA, Zellweger MJ, Cron TA, et al. Value of routine holter monitoring for the detection of paroxysmal atrial fibrillation in patients with cerebral ischemic events. Stroke. 2004;35:e68–70.
Shafqat S, Kelly PJ, Furie KL. Holter monitoring in the diagnosis of stroke mechanism. Intern Med J. 2004;34:305–9.
• Stahrenberg R, Weber-Kruger M, Seegers J, et al. Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm. Stroke. 2010; 41:2884–8. This study confirmed that many patients with stroke have brief (< 30 second) episodes of atrial fibrillation; the clinical significance of this finding remains to be fully elucidated.
Wallmann D, Tuller D, Wustmann K, et al. Frequent atrial premature beats predict paroxysmal atrial fibrillation in stroke patients: an opportunity for a new diagnostic strategy. Stroke. 2007;38:2292–4.
Dion F, Saudeau D, Bonnaud I, et al. Unexpected low prevalence of atrial fibrillation in cryptogenic ischemic stroke: a prospective study. J Interv Card Electrophysiol. 2010;28:101–7.
Ziegler PD, Glotzer TV, Daoud EG, et al. Incidence of newly detected atrial arrhythmias via implantable devices in patients with a history of thromboembolic events. Stroke. 2010;41:256–60.
Tayal AH, Tian M, Kelly KM, et al. Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke. Neurology. 2008;71:1696–701.
Elijovich L, Josephson SA, Fung GL, et al. Intermittent atrial fibrillation may account for a large proportion of otherwise cryptogenic stroke: a study of 30-day cardiac event monitors. J Stroke Cerebrovasc Dis. 2009;18:185–9.
Benjamin EJ, Levy D, Vaziri SM, et al. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA. 1994;271:840–4.
Okada Y, Shibazaki K, Kimura K, et al. Brain natriuretic peptide as a predictor of delayed atrial fibrillation after ischaemic stroke and transient ischaemic attack. Eur J Neurol. 2010;17:326–31.
Montaner J, Perea-Gainza M, Delgado P, et al. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. Stroke. 2008;39:2280–7.
Adams Jr HP, del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007;38:1655–711.
Bell C, Kapral M. Use of ambulatory electrocardiography for the detection of paroxysmal atrial fibrillation in patients with stroke. Canadian Task Force on Preventive Health Care. Can J Neurol Sci. 2000;27:25–31.
Liao J, Khalid Z, Scallan C, et al. Noninvasive cardiac monitoring for detecting paroxysmal atrial fibrillation or flutter after acute ischemic stroke: a systematic review. Stroke. 2007;38:2935–40.
• Kamel H, Hegde M, Johnson DR, et al. Cost-effectiveness of outpatient cardiac monitoring to detect atrial fibrillation after ischemic stroke. Stroke. 2010; 41:1514–20. Concern about the cost of prolonged cardiac monitoring (> 24 hours) has been one rationale for not recommending its routine use after stroke. This study demonstrated that, based on available evidence, 1 week of outpatient cardiac monitoring after stroke is cost-effective.
Disclosure
Hooman Kamel reports no potential conflict of interest relevant to this article. Wade S. Smith has worked as a consultant for Medtronic in the past and is currently working as a paid consultant for and has equity in Concentric Medical.
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Kamel, H., Smith, W.S. Detection of Atrial Fibrillation and Secondary Stroke Prevention Using Telemetry and Ambulatory Cardiac Monitoring. Curr Atheroscler Rep 13, 338–343 (2011). https://doi.org/10.1007/s11883-011-0180-5
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DOI: https://doi.org/10.1007/s11883-011-0180-5