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Understanding Biofilms in Chronic Sinusitis

  • Rhinitis (JJ Oppenheimer and J Corren, Section Editors)
  • Published:
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Abstract

Chronic sinusitis is a burdensome disease that has substantial individual and societal impact. Although great advances in medical and surgical therapies have been made, some patients continue to have recalcitrant infections. Microbial biofilms have been implicated as a cause of recalcitrant chronic sinusitis, and recent studies have tried to better understand the pathogenesis of chronic sinusitis as it relates to microbial biofilms. Here, we provide an overview of biofilms in chronic sinusitis with emphasis on pathogenesis, treatment, and future directions. In addition, recent evidence is presented, elucidating the role of bitter taste receptors as a possible key factor leading to biofilm formation.

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Authors and Affiliations

  1. Department of Otorhinolarygology–Head and Neck Surgery, The University of Pennsylvania, 3400 Spruce Street, 5th Floor Silverstein Bldg., Philadelphia, PA, 19104, USA

    Bobby A. Tajudeen, Joseph S. Schwartz & James N. Palmer

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  1. Bobby A. Tajudeen
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  2. Joseph S. Schwartz
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  3. James N. Palmer
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Correspondence to Bobby A. Tajudeen.

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Drs. Tajudeen, Schwartz, and Palmer declare that they have no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Rhinitis

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Tajudeen, B.A., Schwartz, J.S. & Palmer, J.N. Understanding Biofilms in Chronic Sinusitis. Curr Allergy Asthma Rep 16, 10 (2016). https://doi.org/10.1007/s11882-015-0591-4

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  • DOI: https://doi.org/10.1007/s11882-015-0591-4

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