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What Is the Source of Serum Allergen-Specific IgE?

  • ALLERGENS (RK BUSH, SECTION EDITOR)
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Abstract

Immunoglobulin E (IgE), the key effector element in the induction and propagation of allergic diseases, is the least abundant antibody class. In allergic patients, class switch recombination to IgE in B cells is induced by allergen contact in conjunction with T cell interaction and a Th2 cytokine environment. With regard to future therapeutic approaches, the sites of IgE production in human subjects and the nature and characteristics of IgE-producing cells are of great interest. In this context, it has been shown that allergen-specific IgE levels can be boosted by contact with allergens via the respiratory mucosa of the nose. Also, it has been proposed that allergy effector organs (e.g., the nasal mucosa and the lung) may be important sites of IgE production in allergic patients. IgE-producing cells have also been found in the blood, but their numbers are extremely low. Transfer of specific sensitization during bone marrow transplantation indicates the presence of IgE-producing B memory cells or plasma cells also in the bone marrow. This review summarizes data on the induction of IgE production, IgE memory and the sites of IgE production in human allergic patients.

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Abbreviations

Ig:

Immunoglobulin

CD:

Cluster of differentiation

PBMCs:

Peripheral blood mononuclear cells

IL:

Interleukin

Th2:

T helper 2

mRNA:

Messenger ribonucleic acid

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Acknowledgments

This study was supported by grant SFB04613 of the Austrian Science Fund (FWF).

Conflict of Interest

Julia Eckl-Dorna has received grant support via an FWF SFB04613 grant.

Verena Niederberger has received grant support via SFB04613 of the Austrian Science Fund (FWF), has served as a consultant for Biomay, and has had travel/accommodations expenses covered/reimbursed by GlaxoSmithKline and Stallergenes.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Medical University of Vienna, General Hospital Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria

    Julia Eckl-Dorna & Verena Niederberger

  2. Department of Otorhinolaryngology, Medical University of Vienna, AKH, Ebene 8J, Währinger Gürtel 18-20, 1090, Vienna, Austria

    Verena Niederberger

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  1. Julia Eckl-Dorna
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  2. Verena Niederberger
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Correspondence to Verena Niederberger.

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Eckl-Dorna, J., Niederberger, V. What Is the Source of Serum Allergen-Specific IgE?. Curr Allergy Asthma Rep 13, 281–287 (2013). https://doi.org/10.1007/s11882-013-0348-x

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